Effects of smoking on genome-wide DNA methylation profiles: A study of discordant and concordant monozygotic twin pairs

• Published in: eLife Vol. 12
• Main Authors: van Dongen, Jenny, Willemsen, Gonneke, de Geus, Eco JC, Boomsma, Dorret I, Neale, Michael C
• Format: Journal Article
• Language: English
• Published: Cambridge eLife Sciences Publications Ltd 10.08.2023; eLife Sciences Publications, Ltd
• Subjects: Acetylcholine receptors (nicotinic); Biobanks; Blood cells; Calcium channels (voltage-gated); Channel gating; Cigarette smoking; Consortia; Cotinine; discordant twins; Disease; DNA methylation; Drug abuse; Drug addiction; Epidemiology; Epidemiology and Global Health; Epigenetics; Genetics and Genomics; Genomes; Genotypes; Health behavior; identical twins; Native North Americans; Phenotypes; Quality control; Smoking cessation; Twin studies; twin study; Twins; United States > US; Netherlands

Background: Smoking-associated DNA methylation levels identified through epigenome-wide association studies (EWASs) are generally ascribed to smoking-reactive mechanisms, but the contribution of a shared genetic predisposition to smoking and DNA methylation levels is typically not accounted for. Met...