Proteome Analyses Reveal Positive Association of COL2A1, MPO, TYMS, and IGFBP5 with Canine Mammary Gland Malignancy

• Published in: Proteomics. Clinical applications Vol. 13; no. 4; pp. e1800151 - n/a
• Main Authors: Wu, Chih‐Ching, Chang, Shih‐Chieh, Zeng, Guang‐You, Chu, Hao‐Wei, Huang, Yenlin, Liu, Hao‐Ping
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.07.2019
• Subjects: Animals; Breast cancer; canine mammary tumor; Collagen (type II); Collagen Type II - metabolism; collagen type II alpha 1 chain; Design of experiments; Dogs; Female; Growth factors; Hyperplasia; Immunoblotting; Immunohistochemistry; Insulin; Insulin-Like Growth Factor Binding Protein 5 - metabolism; Insulin-like growth factor-binding protein 5; isobaric tags for relative and absolute quantification (iTRAQ); Malignancy; Mammary gland; Mammary glands; Mammary Neoplasms, Animal - metabolism; Mammary Neoplasms, Animal - pathology; Neoplasia; Neoplasm Proteins - metabolism; Neoplasms; Pathogenesis; Peroxidase; Peroxidase - metabolism; Proteins; Proteome - metabolism; Proteomes; Thymidylate Synthase - metabolism; thymidylate synthetase; Tumors; thymidylate synthetase; canine mammary tumor; insulin-like growth factor-binding protein 5; isobaric tags for relative and absolute quantification (iTRAQ); collagen type II alpha 1 chain

Purpose To identify aberrantly expressed proteins contributing to pathogenesis of canine mammary tumors (CMTs) which are the most prevalent neoplasms in female dogs and include different types. Experimental design Frozen tissue specimens of normal mammary gland (n = 7), lobular hyperplasia (n = 6),...