Synthesis and In Vitro Antibacterial Activities of Novel 2-Aryl-3-(phenylamino)-2,3-dihydroquinazolin-4(1H)-one Derivatives

• Published in: Journal of heterocyclic chemistry Vol. 50; no. 5; pp. 1129 - 1133
• Main Authors: Mohammadi, Ali A., Rohi, Hamed, Soorki, Ali Abolhasani
• Format: Journal Article
• Language: English
• Published: HOBOKEN Blackwell Publishing Ltd 01.09.2013; Wiley; Wiley Subscription Services, Inc
• Subjects: Atoms & subatomic particles; Chemistry; Chemistry, Organic; Derivatives; Physical Sciences; Science & Technology; 2,3-DIHYDROQUINAZOLIN-4(1H)-ONES; EFFICIENT CATALYST; QUINAZOLIN-4(3H)-ONES; ACID; ONE-POT SYNTHESIS; AMINES; IODINE; ALUM; ANHYDRIDE; WATER

An efficient synthesis of novel 2‐aryl‐3‐(phenylamino)‐2,3‐dihydroquinazolin‐4(1H)‐one derivatives using KAl(SO4)2.12H2O (Alum) as a catalyst from an aldehyde and 2‐amino‐N‐phenylbenzohydrazine in ethanol is described. All synthesized derivatives were screened for anti‐bacterial activity. Some compo...