Synthesis and In Vitro Antibacterial Activities of Novel 2-Aryl-3-(phenylamino)-2,3-dihydroquinazolin-4(1H)-one Derivatives

An efficient synthesis of novel 2‐aryl‐3‐(phenylamino)‐2,3‐dihydroquinazolin‐4(1H)‐one derivatives using KAl(SO4)2.12H2O (Alum) as a catalyst from an aldehyde and 2‐amino‐N‐phenylbenzohydrazine in ethanol is described. All synthesized derivatives were screened for anti‐bacterial activity. Some compo...

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Published inJournal of heterocyclic chemistry Vol. 50; no. 5; pp. 1129 - 1133
Main Authors Mohammadi, Ali A., Rohi, Hamed, Soorki, Ali Abolhasani
Format Journal Article
LanguageEnglish
Published HOBOKEN Blackwell Publishing Ltd 01.09.2013
Wiley
Wiley Subscription Services, Inc
Subjects
Atoms & subatomic particles
Chemistry
Chemistry, Organic
Derivatives
Physical Sciences
Science & Technology
2,3-DIHYDROQUINAZOLIN-4(1H)-ONES
EFFICIENT CATALYST
QUINAZOLIN-4(3H)-ONES
ACID
ONE-POT SYNTHESIS
AMINES
IODINE
ALUM
ANHYDRIDE
WATER
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Abstract An efficient synthesis of novel 2‐aryl‐3‐(phenylamino)‐2,3‐dihydroquinazolin‐4(1H)‐one derivatives using KAl(SO4)2.12H2O (Alum) as a catalyst from an aldehyde and 2‐amino‐N‐phenylbenzohydrazine in ethanol is described. All synthesized derivatives were screened for anti‐bacterial activity. Some compounds exhibited promising anti‐bacterial activity with reference to standard antibiotics.
AbstractList An efficient synthesis of novel 2-aryl-3-(phenylamino)-2,3-dihydroquinazolin-4(1H)-one derivatives using KAl(SO4)2.12H2O (Alum) as a catalyst from an aldehyde and 2-amino-N-phenylbenzohydrazine in ethanol is described. All synthesized derivatives were screened for anti-bacterial activity. Some compounds exhibited promising anti-bacterial activity with reference to standard antibiotics.
An efficient synthesis of novel 2-aryl-3-(phenylamino)-2,3-dihydroquinazolin-4(1H) -one derivatives using KAl(SO sub(4)) sub(2).12H sub(2)O (Alum) as a catalyst from an aldehyde and 2-amino-N-phenylbenzohydrazine in ethanol is described. All synthesized derivatives were screened for anti-bacterial activity. Some compounds exhibited promising anti-bacterial activity with reference to standard antibiotics.
An efficient synthesis of novel 2-aryl-3-(phenylamino)-2,3-dihydroquinazolin-4(1H)-one derivatives using KAl(SO4)2.12H2O (Alum) as a catalyst from an aldehyde and 2-amino-N-phenylbenzohydrazine in ethanol is described. All synthesized derivatives were screened for anti-bacterial activity. Some compounds exhibited promising anti-bacterial activity with reference to standard antibiotics. [PUBLICATION ABSTRACT]
An efficient synthesis of novel 2‐aryl‐3‐(phenylamino)‐2,3‐dihydroquinazolin‐4(1 H )‐one derivatives using KAl(SO 4 ) 2 .12H 2 O (Alum) as a catalyst from an aldehyde and 2‐amino‐ N ‐phenylbenzohydrazine in ethanol is described. All synthesized derivatives were screened for anti‐bacterial activity. Some compounds exhibited promising anti‐bacterial activity with reference to standard antibiotics.
Author Mohammadi, Ali A.
Rohi, Hamed
Soorki, Ali Abolhasani
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Issue 5
Keywords 2,3-DIHYDROQUINAZOLIN-4(1H)-ONES
EFFICIENT CATALYST
QUINAZOLIN-4(3H)-ONES
ACID
ONE-POT SYNTHESIS
AMINES
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Snippet An efficient synthesis of novel 2‐aryl‐3‐(phenylamino)‐2,3‐dihydroquinazolin‐4(1H)‐one derivatives using KAl(SO4)2.12H2O (Alum) as a catalyst from an aldehyde...
An efficient synthesis of novel 2-aryl-3-(phenylamino)-2,3-dihydroquinazolin-4(1H)-one derivatives using KAl(SO4)2.12H2O (Alum) as a catalyst from an aldehyde...
An efficient synthesis of novel 2‐aryl‐3‐(phenylamino)‐2,3‐dihydroquinazolin‐4(1 H )‐one derivatives using KAl(SO 4 ) 2 .12H 2 O (Alum) as a catalyst from an...
An efficient synthesis of novel 2-aryl-3-(phenylamino)-2,3-dihydroquinazolin-4(1H) -one derivatives using KAl(SO sub(4)) sub(2).12H sub(2)O (Alum) as a...
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SubjectTerms Atoms & subatomic particles
Chemistry
Chemistry, Organic
Derivatives
Physical Sciences
Science & Technology
Title Synthesis and In Vitro Antibacterial Activities of Novel 2-Aryl-3-(phenylamino)-2,3-dihydroquinazolin-4(1H)-one Derivatives
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