Synthesis and In Vitro Antibacterial Activities of Novel 2-Aryl-3-(phenylamino)-2,3-dihydroquinazolin-4(1H)-one Derivatives

An efficient synthesis of novel 2‐aryl‐3‐(phenylamino)‐2,3‐dihydroquinazolin‐4(1H)‐one derivatives using KAl(SO4)2.12H2O (Alum) as a catalyst from an aldehyde and 2‐amino‐N‐phenylbenzohydrazine in ethanol is described. All synthesized derivatives were screened for anti‐bacterial activity. Some compo...

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Bibliographic Details
Published inJournal of heterocyclic chemistry Vol. 50; no. 5; pp. 1129 - 1133
Main Authors Mohammadi, Ali A., Rohi, Hamed, Soorki, Ali Abolhasani
Format Journal Article
LanguageEnglish
Published HOBOKEN Blackwell Publishing Ltd 01.09.2013
Wiley
Wiley Subscription Services, Inc
Subjects
Atoms & subatomic particles
Chemistry
Chemistry, Organic
Derivatives
Physical Sciences
Science & Technology
2,3-DIHYDROQUINAZOLIN-4(1H)-ONES
EFFICIENT CATALYST
QUINAZOLIN-4(3H)-ONES
ACID
ONE-POT SYNTHESIS
AMINES
IODINE
ALUM
ANHYDRIDE
WATER
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Summary:An efficient synthesis of novel 2‐aryl‐3‐(phenylamino)‐2,3‐dihydroquinazolin‐4(1H)‐one derivatives using KAl(SO4)2.12H2O (Alum) as a catalyst from an aldehyde and 2‐amino‐N‐phenylbenzohydrazine in ethanol is described. All synthesized derivatives were screened for anti‐bacterial activity. Some compounds exhibited promising anti‐bacterial activity with reference to standard antibiotics.
Bibliography:istex:0A3ACAB1833127A916DE3ECC23D54393294D1E75
ArticleID:JHET1075
ark:/67375/WNG-6GJ3V260-8
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.1075