Low‐Dose Coconut Oil Supplementation Induces Hypothalamic Inflammation, Behavioral Dysfunction, and Metabolic Damage in Healthy Mice

• Published in: Molecular nutrition & food research Vol. 65; no. 10; pp. e2000943 - n/a
• Main Authors: Veras, Alana Carolina Costa, Santos, Tamires dos, Martins, Isis de Cássia Alves, Souza, Camilla Mendes, Amaral, Camila Libardi, Franco, Beatriz da Silva, Holanda, Alessandro Spencer de Souza, Esteves, Andrea Maculano, Milanski, Marciane, Torsoni, Adriana Souza, Ignacio‐Souza, Leticia Martins, Torsoni, Marcio Alberto
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.05.2021
• Subjects: Adipose tissue; Body weight; Body weight gain; Carbon monoxide; Chemokines; Coconut oil; Cytokines; Dietary supplements; Dosage; Hypothalamus; Inflammation; Inflammatory response; Leukocyte migration; Macrophages; Metabolic disorders; metabolic parameters; Metabolism; Monocyte chemoattractant protein 1; NF-κB protein; Soybean oil; Soybeans; TLR4 protein; Toll-like receptors; Tumor necrosis factor; adipose tissue; metabolic parameters; inflammation; coconut oil; hypothalamus

Scope Coconut oil (CO) diets remain controversial due to the possible association with metabolic disorder and obesity. This study investigates the metabolic effects of a low amount of CO supplementation. Methods and Results Swiss male mice are assigned to be supplemented orally during 8 weeks with 3...