Mutagenic risk in epileptic patients before and after anticonvulsant therapy

• Published in: Epilepsia (Copenhagen) Vol. 28; no. 1; p. 81
• Main Authors: Goyle, S, Maurya, A K, Kailash, S, Maheshwari, M C
• Format: Journal Article
• Language: English
• Published: United States 01.01.1987
• Subjects: Adolescent; Adult; Age Factors; Anticonvulsants - toxicity; Child; Child, Preschool; Congenital Abnormalities - etiology; Epilepsy - drug therapy; Epilepsy - genetics; Female; Humans; Infant; Male; Middle Aged; Mitotic Index - drug effects; Mutagenicity Tests; Risk; Sex Factors; Sister Chromatid Exchange - drug effects

Therapy with anticonvulsant drugs has often been found to result in somatic chromosome aberrations in adult patients. There is also the possibility of epileptic fathers or mothers playing a role in the production of congenital malformations in their offspring. We have used the technique of sister ch...