Pipoxolan suppresses the inflammatory factors of NF‐κB, AP‐1, and STATs, but activates the antioxidative factor Nrf2 in LPS‐stimulated RAW 264.7 murine macrophage cells - Lin, Yu‐Hsien; Lin, Yu‐Jung; Chang, Ting‐Hsuan; Chang, Yun‐Hsuan; Lim, Yun‐Ping; Chung, Jing‐Gung; Hsieh, Wen‐Tsong (Environmental toxicology, 2020)
Keywords: AKT protein; antioxidative activity; anti‐inflammatory effects; B-lymphocytes; Cells; Cytokines; Cytotoxicity; ecotoxicology; enzyme-linked immunosorbent assay; Heme; inducible nitric oxide synthase; Inflammation; interleukin-6; Interleukins; Janus kinase; Kinases; light; Lipopolysaccharides; Lymphocytes B; Macrophages; mice; Molecular modelling; Muscle relaxants; Muscles; Necrosis; Neoplasms; Nitric oxide; Nitric-oxide synthase; non-specific protein-tyrosine kinase; Oxygenase; pipoxolan (PIPO); Prostaglandin E2; Prostaglandin endoperoxide synthase; prostaglandin synthase; prostaglandins; protein synthesis; Protein-serine/threonine kinase; Proteins; RAW 264.7 cells; Receptors; Serine; signal transduction; Smooth muscle; Threonine; TLR4 protein; Toll-like receptor 4; Toll-like receptors; Toxicity; toxicity testing; transactivators; Transcription; transcription factor; Transcription factors; Transducers; Western blotting