Influence of f-MLP, ACTH(1-24) and CRH on in vitro chemotaxis of monocytes from centenarians

• Published in: Neuroimmunomodulation Vol. 15; no. 4-6; p. 285
• Main Authors: Genedani, Susanna, Filaferro, Monica, Carone, Chiara, Ostan, Rita, Bucci, Laura, Cevenini, Elisa, Franceschi, Claudio, Monti, Daniela
• Format: Journal Article
• Language: English
• Published: Switzerland 01.01.2008
• Subjects: Adrenocorticotropic Hormone - blood; Adult; Aged; Aged, 80 and over; Aging - immunology; Aging - physiology; Chemotaxis, Leukocyte - drug effects; Corticotropin-Releasing Hormone - blood; Corticotropin-Releasing Hormone - pharmacology; Cosyntropin - pharmacology; Humans; Hydrocortisone - blood; Longevity - immunology; Longevity - physiology; Monocytes - drug effects; Monocytes - physiology; N-Formylmethionine Leucyl-Phenylalanine - pharmacology; Neuroimmunomodulation - physiology; Stress, Physiological - immunology; Stress, Physiological - physiology

The lifelong exposure to a variety of stressors activates a plethora of defense mechanisms, including the hypothalamic-pituitary-adrenal axis which releases neuropeptides affecting the immune responses. Here, we report data on the capability of monocytes from young subjects and centenarians to migra...