Parasitologic and clinical human response to immunoglobulin administration in falciparum malaria
The protective effect of African IgG antibodies against Plasmodium falciparum malaria was investigated by passive transfer in Thai patients. Sera from 333 African adults were collected in the Cote d'Ivoire and subjected to extensive screening. One hundred fifty-three samples were discarded for...
Saved in:
Published in | The American journal of tropical medicine and hygiene Vol. 45; no. 3; p. 297 |
---|---|
Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.09.1991
|
Subjects | |
Online Access | Get more information |
Cover
Loading…
Abstract | The protective effect of African IgG antibodies against Plasmodium falciparum malaria was investigated by passive transfer in Thai patients. Sera from 333 African adults were collected in the Cote d'Ivoire and subjected to extensive screening. One hundred fifty-three samples were discarded for safety reasons, and IgG was extracted from those remaining under conditions allowing their use by the intravenous (iv) route. Eight Thai patients with P. falciparum parasitemia were treated by iv inoculation of the IgG: six with a 100 mg/kg dose given over three days, one with a single 20 mg/kg dose, and one with a single 200 mg/kg dose. To ensure a safety margin of at least 48 hours, subjects were chosen among patients having a recrudescent parasitemia following quinine treatment failure at the RI level. At that stage, symptoms were mild or absent and parasitemia was low but increasing (range 4, 200-9,000/microliters). The IgG pool exerted a profound, stage-specific, but non-sterilizing effect on each of the strains tested, and proved to be safe. Asexual parasitemia decreased by a mean 728-fold (range 46-1,086), while gametocytes were unaffected. Clearance of parasites and symptoms was as fast or faster than with drugs, and was consistent in the eight patients treated, suggesting that target antigens were equally expressed in geographically remote isolates. In peripheral blood smears, no mature forms were seen at any time during the followup, which does not support the hypothesis that reversal of cytoadherence occurred. After the disappearance of the transferred antibodies, recrudescent parasites from three patients were found to be susceptible to the same extent (mean decrease of 1,310-fold) to the same IgG preparation, indicating that selection of parasites able to escape the effect of antibodies had not occurred. No adverse side-effects were detected during the followup, which lasted one year. |
---|---|
AbstractList | The protective effect of African IgG antibodies against Plasmodium falciparum malaria was investigated by passive transfer in Thai patients. Sera from 333 African adults were collected in the Cote d'Ivoire and subjected to extensive screening. One hundred fifty-three samples were discarded for safety reasons, and IgG was extracted from those remaining under conditions allowing their use by the intravenous (iv) route. Eight Thai patients with P. falciparum parasitemia were treated by iv inoculation of the IgG: six with a 100 mg/kg dose given over three days, one with a single 20 mg/kg dose, and one with a single 200 mg/kg dose. To ensure a safety margin of at least 48 hours, subjects were chosen among patients having a recrudescent parasitemia following quinine treatment failure at the RI level. At that stage, symptoms were mild or absent and parasitemia was low but increasing (range 4, 200-9,000/microliters). The IgG pool exerted a profound, stage-specific, but non-sterilizing effect on each of the strains tested, and proved to be safe. Asexual parasitemia decreased by a mean 728-fold (range 46-1,086), while gametocytes were unaffected. Clearance of parasites and symptoms was as fast or faster than with drugs, and was consistent in the eight patients treated, suggesting that target antigens were equally expressed in geographically remote isolates. In peripheral blood smears, no mature forms were seen at any time during the followup, which does not support the hypothesis that reversal of cytoadherence occurred. After the disappearance of the transferred antibodies, recrudescent parasites from three patients were found to be susceptible to the same extent (mean decrease of 1,310-fold) to the same IgG preparation, indicating that selection of parasites able to escape the effect of antibodies had not occurred. No adverse side-effects were detected during the followup, which lasted one year. |
Author | Chongsuphajaisiddhi, T Chantavanich, P Druilhe, P Attanath, P Sabchareon, A Foucault, C Burnouf, T Ouattara, D Bouharoun-Tayoun, H |
Author_xml | – sequence: 1 givenname: A surname: Sabchareon fullname: Sabchareon, A organization: Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand – sequence: 2 givenname: T surname: Burnouf fullname: Burnouf, T – sequence: 3 givenname: D surname: Ouattara fullname: Ouattara, D – sequence: 4 givenname: P surname: Attanath fullname: Attanath, P – sequence: 5 givenname: H surname: Bouharoun-Tayoun fullname: Bouharoun-Tayoun, H – sequence: 6 givenname: P surname: Chantavanich fullname: Chantavanich, P – sequence: 7 givenname: C surname: Foucault fullname: Foucault, C – sequence: 8 givenname: T surname: Chongsuphajaisiddhi fullname: Chongsuphajaisiddhi, T – sequence: 9 givenname: P surname: Druilhe fullname: Druilhe, P |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/1928564$$D View this record in MEDLINE/PubMed |
BookMark | eNotj8tKAzEYRrOo1Lb6AC6EvMCMuU0uSylqhYIuuq__ZNI2ZZIMyczCt3fArj44HA58a7SIKTqEniipBZPmBa5juNTUGFqLpmZGLdCKEMIqI7m6R-tSroRQzShdoiU1TDdSrNDPN2Qofkx9OnuLIXbY9j56Cz2-TAEizq4MKRaHx4R9CFNM5z610yxh6MKsljHD6FPEMzlBb_0AeQo4QA_ZwwO6m2Fxj7fdoMP722G7q_ZfH5_b131luVRj5TTXErSVJ96A4Npa7bhrLGdKWSdbpUVLLRjoVCu1OHWs4UQ4JYFw6lq2Qc__2WFqg-uOQ_YB8u_xdpT9AVTlWNo |
CitedBy_id | crossref_primary_10_1371_journal_pone_0185303 crossref_primary_10_1590_S0074_02762011000900005 crossref_primary_10_1093_femsre_fuv046 crossref_primary_10_1016_j_vaccine_2013_11_058 crossref_primary_10_1128_IAI_00928_05 crossref_primary_10_1016_j_ijpara_2012_11_002 crossref_primary_10_1186_1475_2875_10_108 crossref_primary_10_1002_eji_201343630 crossref_primary_10_3389_fimmu_2023_1161301 crossref_primary_10_1016_S0924_4204_02_85012_0 crossref_primary_10_1038_srep31291 crossref_primary_10_1093_infdis_jit134 crossref_primary_10_4049_jimmunol_173_1_666 crossref_primary_10_1016_j_parint_2018_10_012 crossref_primary_10_1111_j_1365_3083_1994_tb03393_x crossref_primary_10_1017_S003118202000061X crossref_primary_10_1016_j_ebiom_2016_05_015 crossref_primary_10_1111_imr_12063 crossref_primary_10_1111_j_1365_3024_2005_00771_x crossref_primary_10_4049_jimmunol_166_10_6236 crossref_primary_10_1016_j_vaccine_2013_09_011 crossref_primary_10_1371_journal_pone_0098460 crossref_primary_10_1080_00034983_2001_11813671 crossref_primary_10_1101_cshperspect_a025627 crossref_primary_10_1128_IAI_73_12_8119_8129_2005 crossref_primary_10_1128_mSphereDirect_00027_19 crossref_primary_10_4269_ajtmh_17_0343 crossref_primary_10_1074_jbc_M109_092619 crossref_primary_10_1084_jem_192_11_1653 crossref_primary_10_1016_j_smim_2018_08_002 crossref_primary_10_1186_s12865_018_0271_y crossref_primary_10_1186_s12936_017_1762_7 crossref_primary_10_1186_s12879_021_06027_5 crossref_primary_10_1038_s41467_019_09894_4 crossref_primary_10_1371_journal_pone_0149581 crossref_primary_10_1136_pgmj_2004_020891 crossref_primary_10_1016_S1369_5274_02_00348_X crossref_primary_10_1186_s12936_015_0547_0 crossref_primary_10_1016_0169_4758_95_80166_9 crossref_primary_10_1111_j_1365_2249_1992_tb05851_x crossref_primary_10_1080_00034983_1998_11813304 crossref_primary_10_1128_IAI_69_9_5223_5229_2001 crossref_primary_10_1016_j_actatropica_2005_06_012 crossref_primary_10_1016_j_vaccine_2008_06_031 crossref_primary_10_1128_IAI_67_1_64_73_1999 crossref_primary_10_1186_s12916_014_0134_1 crossref_primary_10_1128_IAI_00573_06 crossref_primary_10_4049_jimmunol_1403206 crossref_primary_10_1038_s41598_018_27361_w crossref_primary_10_1186_s12936_019_3035_0 crossref_primary_10_1111_j_0141_9838_2004_00703_x crossref_primary_10_1016_S0264_410X_00_00181_X crossref_primary_10_1517_17460441_3_4_415 crossref_primary_10_1186_1475_2875_8_43 crossref_primary_10_4049_jimmunol_1502199 crossref_primary_10_1371_journal_pone_0124297 crossref_primary_10_1017_S0031182007000121 crossref_primary_10_1016_S2352_3026_20_30288_X crossref_primary_10_26508_lsa_202301910 crossref_primary_10_1186_s13071_019_3846_4 crossref_primary_10_1590_S0074_02762011000900023 crossref_primary_10_1016_j_ijpara_2017_05_004 crossref_primary_10_1016_j_actatropica_2011_04_012 crossref_primary_10_4049_jimmunol_1103177 crossref_primary_10_4049_jimmunol_2300525 crossref_primary_10_1186_s12936_016_1131_y crossref_primary_10_1586_14760584_2016_1141680 crossref_primary_10_1056_NEJMoa2101746 crossref_primary_10_1016_S0169_4758_97_01040_5 crossref_primary_10_1128_IAI_74_5_2867_2875_2006 crossref_primary_10_1371_journal_pone_0107965 crossref_primary_10_1016_j_transci_2014_10_003 crossref_primary_10_1128_IAI_00941_08 crossref_primary_10_1007_s00439_011_1076_8 crossref_primary_10_1016_0165_2478_94_90118_X crossref_primary_10_1016_S0165_2478_02_00159_1 crossref_primary_10_1016_j_vaccine_2009_02_081 crossref_primary_10_1172_JCI44423 crossref_primary_10_3389_fcimb_2023_1169552 crossref_primary_10_1186_s12936_019_2764_4 crossref_primary_10_1371_journal_pone_0015007 crossref_primary_10_1371_journal_pone_0072504 crossref_primary_10_1038_ni_f_205 crossref_primary_10_1046_j_1365_3024_2002_00456_x crossref_primary_10_1073_pnas_0501808102 crossref_primary_10_1128_IAI_00982_08 crossref_primary_10_7554_eLife_79245 crossref_primary_10_1128_IAI_02398_14 crossref_primary_10_1080_00034983_1997_11813238 crossref_primary_10_3390_vaccines9020115 crossref_primary_10_1371_journal_pone_0052939 crossref_primary_10_1128_IAI_00122_09 crossref_primary_10_1128_IAI_73_1_422_430_2005 crossref_primary_10_3389_fimmu_2020_00204 crossref_primary_10_1128_IAI_00778_19 crossref_primary_10_1128_IAI_70_8_4329_4335_2002 crossref_primary_10_1371_journal_pone_0232786 crossref_primary_10_1016_0923_2494_96_82048_7 crossref_primary_10_1017_S1462399409001318 crossref_primary_10_1371_journal_ppat_1005999 crossref_primary_10_1371_journal_pmed_1000218 crossref_primary_10_1006_expr_2001_4619 crossref_primary_10_1371_journal_pone_0073624 crossref_primary_10_1186_1475_2875_7_142 crossref_primary_10_1637_10738_112913_Reg crossref_primary_10_1128_IAI_00360_09 crossref_primary_10_1186_s12936_015_0605_7 crossref_primary_10_1016_S0923_2494_94_80179_7 crossref_primary_10_1038_415694a crossref_primary_10_1186_1475_2875_11_367 crossref_primary_10_1128_IAI_01359_08 crossref_primary_10_1073_pnas_0608889104 crossref_primary_10_1016_j_vaccine_2015_09_059 crossref_primary_10_1111_tan_12140 crossref_primary_10_1371_journal_ppat_1004894 crossref_primary_10_1371_journal_pone_0174718 crossref_primary_10_1046_j_1365_2249_2002_01972_x crossref_primary_10_1093_oxfimm_iqab008 crossref_primary_10_1189_jlb_4A0614_283RR crossref_primary_10_1017_S0031182015001249 crossref_primary_10_4049_jimmunol_1900725 crossref_primary_10_1016_S0166_6851_97_00065_0 crossref_primary_10_1016_S0166_6851_97_00125_4 crossref_primary_10_1038_s41467_019_08528_z crossref_primary_10_1242_jeb_00615 crossref_primary_10_3389_fimmu_2020_608016 crossref_primary_10_1111_j_0141_9838_2004_00705_x crossref_primary_10_1016_j_actatropica_2013_10_018 crossref_primary_10_1128_IAI_72_1_247_252_2004 crossref_primary_10_1186_s12936_015_0911_0 crossref_primary_10_1016_j_pt_2009_02_006 crossref_primary_10_1111_pim_12212 crossref_primary_10_1007_s12016_009_8155_9 crossref_primary_10_1017_S0031182006001843 crossref_primary_10_1016_j_peptides_2008_10_022 crossref_primary_10_1128_IAI_69_5_3286_3294_2001 crossref_primary_10_1128_IAI_00271_15 crossref_primary_10_1186_1475_2875_11_343 crossref_primary_10_1016_j_mib_2016_04_006 crossref_primary_10_1371_journal_pone_0005410 crossref_primary_10_1016_0001_706X_94_90072_8 crossref_primary_10_1089_153685902321044016 crossref_primary_10_1038_srep03549 crossref_primary_10_1371_journal_pone_0121643 crossref_primary_10_1093_infdis_jir223 crossref_primary_10_1111_j_0818_9641_2004_01265_x crossref_primary_10_3389_fimmu_2022_899223 crossref_primary_10_1038_s41467_023_40878_7 crossref_primary_10_1371_journal_pone_0022525 crossref_primary_10_1016_j_vaccine_2008_02_020 crossref_primary_10_1186_1471_2334_10_55 crossref_primary_10_1186_s12936_015_0567_9 crossref_primary_10_4161_hv_6_8_11446 crossref_primary_10_1074_mcp_M111_008326 crossref_primary_10_1016_j_vaccine_2013_06_042 crossref_primary_10_1016_j_vaccine_2006_09_074 crossref_primary_10_1371_journal_pntd_0005323 crossref_primary_10_1126_science_1254417 crossref_primary_10_1371_journal_pone_0009309 crossref_primary_10_1016_S0264_410X_00_00036_0 crossref_primary_10_4049_jimmunol_178_5_3099 crossref_primary_10_1016_j_medmal_2006_05_016 crossref_primary_10_1007_BF00870265 crossref_primary_10_1007_s12639_020_01288_4 crossref_primary_10_1128_IAI_69_4_2535_2541_2001 crossref_primary_10_1186_s12936_017_1731_1 crossref_primary_10_1186_1741_7015_12_108 crossref_primary_10_1371_journal_ppat_1004858 crossref_primary_10_1101_cshperspect_a025577 crossref_primary_10_1371_journal_ppat_0030138 crossref_primary_10_1186_1475_2875_9_115 crossref_primary_10_4269_ajtmh_16_0690 crossref_primary_10_1016_S0166_6851_01_00394_2 crossref_primary_10_1128_IAI_69_7_4390_4397_2001 crossref_primary_10_1016_S0166_6851_01_00428_5 crossref_primary_10_1186_s12936_016_1337_z crossref_primary_10_1093_cid_ciu954 crossref_primary_10_1586_14760584_7_4_499 crossref_primary_10_1016_j_vaccine_2010_07_085 crossref_primary_10_1038_s41541_020_0196_3 crossref_primary_10_1007_s00508_010_1330_4 crossref_primary_10_1080_00034983_1999_11813470 crossref_primary_10_1371_journal_pone_0025582 crossref_primary_10_1186_s12936_022_04374_5 crossref_primary_10_1371_journal_ppat_1004855 crossref_primary_10_1007_s10875_017_0426_2 crossref_primary_10_1371_journal_pmed_0020344 crossref_primary_10_1371_journal_pone_0015424 crossref_primary_10_1016_j_vaccine_2004_05_031 crossref_primary_10_1128_IAI_67_6_2975_2985_1999 crossref_primary_10_1016_S0399_077X_00_87129_2 crossref_primary_10_1016_j_apjtb_2017_09_017 crossref_primary_10_1128_IAI_71_9_4961_4969_2003 crossref_primary_10_1073_pnas_1200472109 crossref_primary_10_1016_j_exppara_2004_07_004 crossref_primary_10_1128_IAI_73_12_8017_8026_2005 crossref_primary_10_3390_tropicalmed6040185 crossref_primary_10_1006_clim_2001_5057 crossref_primary_10_1016_j_ijpara_2004_04_007 crossref_primary_10_1371_journal_ppat_1004715 crossref_primary_10_3389_fimmu_2019_00135 crossref_primary_10_1371_journal_pone_0028165 crossref_primary_10_1146_annurev_micro_090817_062427 crossref_primary_10_1128_mSphere_00726_21 crossref_primary_10_1016_j_vaccine_2008_09_081 crossref_primary_10_1186_1475_2875_12_100 crossref_primary_10_1016_j_it_2021_04_006 crossref_primary_10_1042_BA20050144 crossref_primary_10_1371_journal_ppat_1009288 crossref_primary_10_1016_S0264_410X_01_00273_0 crossref_primary_10_1186_s12936_019_2915_7 crossref_primary_10_1128_IAI_05961_11 crossref_primary_10_1098_rstb_1997_0121 crossref_primary_10_1186_1475_2875_13_136 crossref_primary_10_3389_fcimb_2023_1076150 crossref_primary_10_1179_000349803225001472 crossref_primary_10_4269_ajtmh_18_0805 crossref_primary_10_3389_fmicb_2014_00741 crossref_primary_10_1016_0923_2494_91_90141_5 crossref_primary_10_1016_j_vaccine_2021_06_024 crossref_primary_10_3389_fimmu_2022_894770 crossref_primary_10_1016_j_pt_2023_08_006 crossref_primary_10_1128_CVI_00156_13 crossref_primary_10_1182_blood_2005_10_4094 crossref_primary_10_1016_0001_706X_96_00014_9 crossref_primary_10_1186_s12936_017_2097_0 crossref_primary_10_1016_j_vaccine_2009_09_011 crossref_primary_10_1128_IAI_68_5_2617_2620_2000 crossref_primary_10_1186_s12936_015_0797_x crossref_primary_10_1373_clinchem_2006_081695 crossref_primary_10_2217_fvl_10_24 crossref_primary_10_1074_mcp_M113_036632 crossref_primary_10_1016_j_ebiom_2017_08_030 crossref_primary_10_1002_prca_201100021 crossref_primary_10_1128_IAI_01972_14 crossref_primary_10_1007_s10096_018_3313_8 crossref_primary_10_1016_j_vaccine_2015_10_058 crossref_primary_10_1017_S0031182004006328 crossref_primary_10_1590_0074_02760150241 crossref_primary_10_1016_j_vaccine_2018_03_023 crossref_primary_10_1111_j_1365_3024_2003_00647_x crossref_primary_10_1128_CVI_00042_09 crossref_primary_10_1016_j_vaccine_2012_01_010 crossref_primary_10_1017_S0031182015001092 crossref_primary_10_4049_jimmunol_1202438 crossref_primary_10_1182_blood_2011_08_376111 crossref_primary_10_1186_s12936_019_2771_5 crossref_primary_10_1016_S0213_005X_08_76228_1 crossref_primary_10_1111_imr_12822 crossref_primary_10_1080_14760584_2017_1355246 crossref_primary_10_1128_CMR_00025_08 crossref_primary_10_1016_j_meegid_2014_02_011 crossref_primary_10_1371_journal_pone_0148723 crossref_primary_10_1155_2016_5381956 crossref_primary_10_3389_fimmu_2017_00126 crossref_primary_10_1155_2010_198921 crossref_primary_10_1016_S0169_4758_97_01095_8 crossref_primary_10_1186_s12936_020_03548_3 crossref_primary_10_1016_S0161_5890_01_00080_3 crossref_primary_10_1016_j_vaccine_2008_10_025 crossref_primary_10_1080_14787210_2017_1328278 crossref_primary_10_3390_vaccines10091525 crossref_primary_10_1016_j_vaccine_2007_10_042 crossref_primary_10_1128_CVI_05523_11 crossref_primary_10_1146_annurev_immunol_042617_053301 crossref_primary_10_1016_0022_1759_93_90408_Y crossref_primary_10_1016_j_vaccine_2017_01_001 crossref_primary_10_1128_IAI_01147_07 crossref_primary_10_1186_1475_2875_10_13 crossref_primary_10_1186_s13104_021_05818_y crossref_primary_10_5005_jp_journals_10028_1608 crossref_primary_10_1111_j_1365_3083_2007_01947_x crossref_primary_10_1371_journal_pone_0015983 crossref_primary_10_1111_j_1600_065X_1999_tb01344_x crossref_primary_10_1186_s12936_018_2369_3 crossref_primary_10_1016_j_pt_2008_08_008 crossref_primary_10_1093_infdis_jiw617 crossref_primary_10_1128_IAI_00262_15 crossref_primary_10_1111_imm_12997 crossref_primary_10_1017_S0031182015000670 crossref_primary_10_4049_jimmunol_1400325 crossref_primary_10_1128_cmr_00071_23 crossref_primary_10_1016_j_micinf_2008_03_001 crossref_primary_10_1371_journal_ppat_1000690 crossref_primary_10_1128_IAI_71_8_4749_4758_2003 crossref_primary_10_1128_IAI_00593_10 crossref_primary_10_1128_IAI_68_5_2899_2906_2000 crossref_primary_10_1186_1475_2875_4_48 crossref_primary_10_1016_0923_2494_91_90140_E crossref_primary_10_1128_IAI_68_7_4312_4318_2000 crossref_primary_10_1016_j_ijpara_2010_08_002 crossref_primary_10_1021_js960147h crossref_primary_10_1371_journal_pcbi_1009801 crossref_primary_10_1371_journal_pone_0124412 crossref_primary_10_1371_journal_pntd_0001934 crossref_primary_10_4049_jimmunol_1203067 crossref_primary_10_1128_IAI_00939_09 crossref_primary_10_1371_journal_pone_0166135 crossref_primary_10_1038_gene_2015_59 crossref_primary_10_1128_IAI_71_4_2173_2181_2003 crossref_primary_10_1111_j_1365_3156_2007_01994_x crossref_primary_10_1016_0035_9203_92_90147_5 crossref_primary_10_1016_j_micinf_2007_02_009 crossref_primary_10_1016_j_parint_2020_102224 crossref_primary_10_4049_jimmunol_161_4_1908 crossref_primary_10_1016_j_micinf_2007_02_008 crossref_primary_10_3389_fimmu_2020_594653 crossref_primary_10_1046_j_1365_3024_2001_00419_x crossref_primary_10_3389_fimmu_2019_01771 crossref_primary_10_1111_j_1365_3083_2007_01972_x crossref_primary_10_1016_j_actatropica_2018_02_030 crossref_primary_10_1038_nm_3083 crossref_primary_10_1093_infdis_jiad115 crossref_primary_10_1128_IAI_73_2_1235_1238_2005 crossref_primary_10_1038_s41541_017_0015_7 crossref_primary_10_1080_14760584_2021_1981864 crossref_primary_10_1016_j_vaccine_2018_08_058 crossref_primary_10_1111_j_1365_3083_2012_02690_x crossref_primary_10_1016_0169_4758_95_80167_7 crossref_primary_10_1016_0923_2494_96_80261_6 |
ContentType | Journal Article |
DBID | CGR CUY CVF ECM EIF NPM |
DOI | 10.4269/ajtmh.1991.45.297 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | no_fulltext_linktorsrc |
Discipline | Medicine |
ExternalDocumentID | 1928564 |
Genre | Clinical Trial Journal Article |
GroupedDBID | --- .55 .GJ 1CY 23M 2WC 34G 36B 3O- 53G 5GY 5RE 5VS 6J9 ABCQX ABPPZ ABTNK ACGFO ADBBV ADTPD AENEX AFFNX AGCDD AI. AIAGR ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BTFSW CGR CUY CVF DIK E3Z EBD EBS ECM EIF EJD EMB EMOBN F5P GX1 H13 HYE K-O KQ8 L7B MV1 NEJ NPM OHT OK1 P2P PQQKQ RHF RHI RPM SV3 TR2 TST UPT VH1 W8F WH7 WOQ WOW X7M XOL ZGI ZKB ZXP ~KM |
ID | FETCH-LOGICAL-c367t-e8386a8c6f35a438cc8e3e5c3277ce6b784b1ca9ad7b684fd25304e76a031eb2 |
ISSN | 0002-9637 |
IngestDate | Sat Sep 28 08:40:37 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 3 |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c367t-e8386a8c6f35a438cc8e3e5c3277ce6b784b1ca9ad7b684fd25304e76a031eb2 |
PMID | 1928564 |
ParticipantIDs | pubmed_primary_1928564 |
PublicationCentury | 1900 |
PublicationDate | 1991-Sep |
PublicationDateYYYYMMDD | 1991-09-01 |
PublicationDate_xml | – month: 09 year: 1991 text: 1991-Sep |
PublicationDecade | 1990 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | The American journal of tropical medicine and hygiene |
PublicationTitleAlternate | Am J Trop Med Hyg |
PublicationYear | 1991 |
SSID | ssj0018211 |
Score | 1.9177641 |
Snippet | The protective effect of African IgG antibodies against Plasmodium falciparum malaria was investigated by passive transfer in Thai patients. Sera from 333... |
SourceID | pubmed |
SourceType | Index Database |
StartPage | 297 |
SubjectTerms | Adult Animals Antibodies, Protozoan - therapeutic use Follow-Up Studies Humans Immunization, Passive Immunoglobulin G - therapeutic use Immunoglobulins, Intravenous - therapeutic use Leukocyte Count Liver - pathology Malaria, Falciparum - immunology Malaria, Falciparum - therapy Plasmodium falciparum - immunology Plasmodium vivax - growth & development Spleen - pathology |
Title | Parasitologic and clinical human response to immunoglobulin administration in falciparum malaria |
URI | https://www.ncbi.nlm.nih.gov/pubmed/1928564 |
Volume | 45 |
hasFullText | |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLa6IdBeELcJxkB-4A2l1LFjO4_TNDQhbSBRpL0N23FYJ9pUmfvAfgc_mONL2qRcBLxEld06Tr6vx8f2-Y4RelWawviRMZtYChOUmvCs1AXJzKSsmNGE2JCs-uycn35i7y6Ki9Hoey9qaeX02Nz-UlfyP6hCGeDqVbL_gOy6USiAz4AvXAFhuP4Vxh9Uq25mLtqvqFDrhI7x7L02RsCG4zFmXgnS-AQgIfhcDbLm-mWPWn31Adbtav56rmDCO1N9z3W6kaAs-vkmXNsswx27XfrQj6tvX8BmrEnzUWkv77LpAOv1GgC00qzqQaz2-5VyTrVqEI18BEV-lX8jSKuSco-sI7H6xhf-76JvfGMuyUQy2rekMWx328J75a0fvq7d_MorLcmYFeOt7wJIy3mAHNxXWcQs6X-s3Eq5nWp20I6Q_jiQc78ClHamZE5IN6XyDxN3yn233vzUqT10NzW1NWkJzsv0AbqfZh34KFLoIRrZxSN07ywh9hh9HjAJA4K4YxIOTMIdk7Br8JBJeMgkDCUbJuHEpCdo-vZkenyapbM3MkO5cJmVVHIlDa9poRiVxkhLbWFoLoSxXAvJNDGqVJXQXLK6ygs6YVZwBaOE1fk-2l00C_sU4Qq8eMVZ2BNmZS11VeeCwA8mQpemVM_Qfnw1l8uYX-UyvbOD31U8R3sbfh2iO_BQN_YF-IZOvwxg_QBsfmgT |
link.rule.ids | 780 |
linkProvider | National Library of Medicine |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Parasitologic+and+clinical+human+response+to+immunoglobulin+administration+in+falciparum+malaria&rft.jtitle=The+American+journal+of+tropical+medicine+and+hygiene&rft.au=Sabchareon%2C+A&rft.au=Burnouf%2C+T&rft.au=Ouattara%2C+D&rft.au=Attanath%2C+P&rft.date=1991-09-01&rft.issn=0002-9637&rft.volume=45&rft.issue=3&rft.spage=297&rft_id=info:doi/10.4269%2Fajtmh.1991.45.297&rft_id=info%3Apmid%2F1928564&rft_id=info%3Apmid%2F1928564&rft.externalDocID=1928564 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0002-9637&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0002-9637&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0002-9637&client=summon |