Lower Expression of Tight Junction Protein 1 Gene and Increased FOXP3 Expression in the Small Bowel Mucosa in Coeliac Disease and Associated Type 1 Diabetes Mellitus

• Published in: International archives of allergy and immunology Vol. 156; no. 4; pp. 451 - 461
• Main Authors: Vorobjova, Tamara, Uibo, Oivi, Ojakivi, Ivi, Teesalu, Kaupo, Panarina, Marina, Heilman, Kaire, Uibo, Raivo
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland Karger 01.01.2011
• Subjects: Adolescent; Biological and medical sciences; Celiac Disease - complications; Celiac Disease - genetics; Celiac Disease - immunology; Child; Child, Preschool; Diabetes Mellitus, Type 1 - complications; Diabetes Mellitus, Type 1 - genetics; Diabetes Mellitus, Type 1 - immunology; Female; Forkhead Transcription Factors - genetics; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Gastroenterology. Liver. Pancreas. Abdomen; Gene Expression Regulation; Gliadin - immunology; Humans; Immunoglobulin A - immunology; Immunoglobulin G - immunology; Immunopathology; Intestinal Mucosa - immunology; Intestinal Mucosa - metabolism; Intestine, Small - immunology; Intestine, Small - metabolism; Male; Medical sciences; Membrane Proteins - genetics; Original Paper; Other diseases. Semiology; Phosphoproteins - genetics; RNA, Messenger - metabolism; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Zonula Occludens-1 Protein; IgA antibodies; IgG antibodies; Type 1 diabetes; Tight junction protein 1; Coeliac disease; Regulatory T cells; Food antigens; FOXP3; Endocrinopathy; IgA; Cell junction; IgG; Autoimmune disease; Small intestine; Immunology; Intestinal malabsorption; T-Lymphocyte; Intestinal disease; Regulatory cell; Transcription factor FOXP3; Food; Immunopathology; Immunoglobulins; Digestive system; Antibody; Gene expression; Protein; Antigen; Digestive diseases; Tight junction; Mucosa disease

Background: The role of regulatory T cells expressing FOXP3 in the pathogenesis of coeliac disease (CD) and type 1 diabetes (T1D) has been reported. Recent data have placed special focus on the interplay between the intestinal barrier and immunoregulatory processes. We aimed to determine whether the...