Effects of dexamethasone on cell-mediated immune responses in cattle sensitized to Mycobacterium bovis

• Published in: American journal of veterinary research Vol. 56; no. 10; p. 1300
• Main Authors: Doherty, M.L. (University College Dublin, Dublin, Ireland.), Bassett, H.F, Quinn, P.J, Davis, W.C, Monaghan, M.L
• Format: Journal Article
• Language: English
• Published: United States 01.10.1995
• Subjects: Animals; Anti-Inflammatory Agents - pharmacology; BOVIN; Cattle; CD2 Antigens - immunology; CD4-Positive T-Lymphocytes - drug effects; CD4-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - drug effects; CD8-Positive T-Lymphocytes - immunology; DEXAMETASONA; DEXAMETHASONE; Dexamethasone - pharmacology; EXPERIMENTACION IN VITRO; EXPERIMENTATION IN VITRO; Female; Flow Cytometry - veterinary; GANADO BOVINO; IMMUNITE CELLULAIRE; Immunity, Cellular - drug effects; Immunization - veterinary; Immunohistochemistry; INMUNIDAD CELULAR; INTERFERON; Interferon-gamma - biosynthesis; INTERFERONAS; Leukocyte Count - veterinary; LINFOCITOS; LYMPHOCYTE; MEDICAMENT; MEDICAMENTOS; MYCOBACTERIUM; Mycobacterium bovis - immunology; PRUEBAS CUTANEAS; Receptors, Antigen, T-Cell, gamma-delta - immunology; Receptors, Interleukin-2 - immunology; REPONSE IMMUNITAIRE; RESPUESTA INMUNOLOGICA; Skin - drug effects; Skin - immunology; TEST CUTANE; Tuberculin - pharmacology; Tuberculin Test - veterinary; TUBERCULINA; TUBERCULINE; Tuberculosis, Bovine - immunology

Systemic administration of dexamethasone led to a significant reduction in the size of the tuberculin reaction in response to intradermal injection of bovine purified protein derivative in 18 cattle experimentally sensitized to Mycobacterium bovis (P 0.01) and 8 cattle naturally infected with M bovi...