Distinct Role of Parvalbumin Expressing Neurons in the Reticular Thalamic Nucleus in Nociception

• Published in: Experimental neurobiology Vol. 32; no. 6; pp. 387 - 394
• Main Authors: Park, Sanggeon, Cho, Jeiwon, Huh, Yeowool
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Society for Brain and Neural Sciences 31.12.2023; 한국뇌신경과학회
• Subjects: Original; 뇌과학; Mice; Optogenetics; Interneurons; Somatostatin; Parvalbumin; Thalamus reticulate nucleus

Loss of inhibition is suggested to cause pathological pain symptoms. Indeed, some human case reports suggest that lesions including the thalamic reticular nucleus (TRN) which provides major inhibitory inputs to other thalamic nuclei, may induce thalamic pain, a type of neuropathic pain. In support,...