Synthesis of distamycin A polyamides targeting G-quadruplex DNA

• Published in: Organic & biomolecular chemistry Vol. 4; no. 18; pp. 3479 - 3488
• Main Authors: Moore, Michael J. B., Cuenca, Francisco, Searcey, Mark, Neidle, Stephen
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 01.01.2006
• Subjects: Chemistry; Chemistry, Organic; Dimerization; Distamycins - chemical synthesis; Distamycins - chemistry; DNA - chemistry; Fluorescence Resonance Energy Transfer; G-Quadruplexes; Humans; Models, Molecular; Nylons - chemical synthesis; Nylons - chemistry; Physical Sciences; Science & Technology; Thermodynamics; CELLS; MINOR-GROOVE RECOGNITION; HUMAN TELOMERASE INHIBITION; LIGANDS; SOLID-PHASE SYNTHESIS; ANTITUMOR POLYCYCLIC ACRIDINES; BIOLOGICAL-ACTIVITY; SENESCENCE; IMIDAZOLE; BINDING

A number of amide-linked oligopyrroles based on distamycin molecules have been synthesized by solid-state methods, and their interactions with a human intramolecular G-quadruplex have been measured by a melting procedure. Several of these molecules show an enhanced ratio of quadruplex vs. duplex DNA...