Assessing the importance of sex in a hippocampus-dependent behavioral test battery in C57BL/6NTac mice

• Published in: Learning & memory (Cold Spring Harbor, N.Y.) Vol. 29; no. 8; pp. 203 - 215
• Main Authors: Stevanovic, Korey D., Fry, Sydney A., DeFilipp, Jemma M.S., Wu, Nicholas, Bernstein, Briana J., Cushman, Jesse D.
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.08.2022
• Subjects: Animals; Anxiety Disorders; Auditory Stimuli; Behavior Rating Scale; Brain Hemisphere Functions; Cognitive ability; Conditioning; Cues; Emotional Response; Fear; Fear - physiology; Fear conditioning; Female; Females; Gender Differences; Genetics; Habituation; Hippocampus; Hippocampus - physiology; Humans; Male; Mice; Mice, Inbred C57BL; Nervous system; Pattern recognition; Sex; Sex differences; Spontaneous alternation

Inclusion of male and female subjects in behavioral neuroscience research requires a concerted effort to characterize sex differences in standardized behavioral assays. Sex differences in hippocampus-dependent assays have been widely reported but are still poorly characterized. In the present study,...