ZBED3 exacerbates hyperglycemia by promoting hepatic gluconeogenesis through CREB signaling

• Published in: Metabolism, clinical and experimental Vol. 162; p. 156049
• Main Authors: Luo, Yuan-yuan, Ruan, Chang-shun, Zhao, Fu-zhen, Yang, Min, Cui, Wei, Cheng, Xi, Luo, Xiao-he, Zhang, Xian-xiang, Zhang, Cheng
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2025
• Subjects: Animals; CREB; Cyclic AMP Response Element-Binding Protein - metabolism; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - metabolism; Gluconeogenesis - genetics; Gluconeogenesis - physiology; Hepatic gluconeogenesis; Hepatocytes - metabolism; Hyperglycemia - metabolism; Insulin Resistance; Liver - metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; PRMT5; Signal Transduction - physiology; Transcription Factors - genetics; Transcription Factors - metabolism; ZBED3; T2DM; CRTC2; NAFLD; GWAS; LDL-C; GTT; HFD; LW; cAMP; FPKM; co-IP; H3R2me2-s; HDL-C; DMEM; PTT; scRNA-seq; CREB; s-DMA; BW; FBS; NEFA; SNPs; PCK1; ZBED3; UMAP; PRMT5; G6PC; IP-MS; GCGR; Hepatic gluconeogenesis; PKA; PRMTs; GSEA; GST; IR; eWAT; MPHs; PGC-1α; NASH; NCD; PCA; TC; GEO; HGP; TG; AAV

Elevated hepatic glucose production (HGP) is a prominent manifestation of impaired hepatic glucose metabolism in individuals with diabetes. Increased hepatic gluconeogenesis plays a pivotal role in the dysregulation of hepatic glucose metabolism and contributes significantly to fasting hyperglycemia...