miRNA Signatures in Alveolar Macrophages Related to Cigarette Smoke: Assessment and Bioinformatics Analysis

• Published in: International journal of molecular sciences Vol. 26; no. 3; p. 1277
• Main Authors: Mirra, Davida, Esposito, Renata, Spaziano, Giuseppe, Rafaniello, Concetta, Panico, Francesca, Squillante, Antonio, Falciani, Maddalena, Abrego-Guandique, Diana Marisol, Caiazzo, Eleonora, Gallelli, Luca, Cione, Erika, D’Agostino, Bruno
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.02.2025; MDPI
• Subjects: Adult; Aged; Bioinformatics; Cancer; Case-Control Studies; Cell cycle; Chronic obstructive pulmonary disease; Cigarette Smoking - adverse effects; Cigarette Smoking - genetics; Computational Biology - methods; Development and progression; DNA methylation; Epigenetic inheritance; Female; Gene expression; Gene Expression Profiling; Gene Expression Regulation; Genes; Humans; Immune system; Inflammation; Lung cancer; Lung cancer, Non-small cell; Lung diseases; Lung diseases, Obstructive; Macrophages; Macrophages, Alveolar - drug effects; Macrophages, Alveolar - metabolism; Male; Metabolism; MicroRNA; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; Middle Aged; Mutation; Oxidative stress; Pulmonary Disease, Chronic Obstructive - genetics; Pulmonary Disease, Chronic Obstructive - metabolism; Risk factors; Signal transduction; Smoke - adverse effects; Smokers; Smoking; Smoking - adverse effects; Italy; lung cancer; microRNAs; cigarette smoke; alveolar macrophages; COPD

 Cigarette smoke (CS) is a driver of many respiratory diseases, including chronic obstructive pulmonary disease (COPD) and non-small cell lung cancer (NSCLC). Tobacco causes oxidative stress, impaired phagocytosis of alveolar macrophages (AMs), and alterations in gene expression in the lungs of smok...