Robust B Cell Immunity but Impaired T Cell Proliferation in the Absence of CD134 (OX40)

• Published in: The Journal of immunology (1950) Vol. 163; no. 12; pp. 6520 - 6529
• Main Authors: Pippig, Susanne D, Pena-Rossi, Claudia, Long, James, Godfrey, Wayne R, Fowell, Deborah J, Reiner, Steven L, Birkeland, Marian L, Locksley, Richard M, Barclay, A. Neil, Killeen, Nigel
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 15.12.1999
• Subjects: Animals; Antibodies, Helminth - biosynthesis; Antibodies, Protozoan - biosynthesis; B-Lymphocytes - immunology; B-Lymphocytes - metabolism; CD134 antigen; Female; Gene Targeting; Immunity, Cellular - genetics; Leishmania major - immunology; Lymphocyte Activation - genetics; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Mutant Strains; Nippostrongylus - immunology; OX40 antigen; Receptors, OX40; Receptors, Tumor Necrosis Factor - biosynthesis; Receptors, Tumor Necrosis Factor - genetics; Receptors, Tumor Necrosis Factor - physiology; T-Lymphocytes - immunology; Tumor Necrosis Factor Receptor Superfamily, Member 7 - biosynthesis; Tumor Necrosis Factor Receptor Superfamily, Member 7 - genetics; Tumor Necrosis Factor Receptor Superfamily, Member 7 - physiology
• ISSN: 0022-1767; 1550-6606
• DOI: 10.4049/jimmunol.163.12.6520

CD134 (OX40) is a member of the TNF receptor family that is expressed on activated T lymphocytes. T cells from mice that lack expression of CD134 made strong responses to a range of challenges, but they showed impaired proliferation in response to direct stimulation through the TCR with monoclonal anti-CD3epsilon Ab. CD134-deficient mice controlled infection with Leishmania major, Nippostrongylus brasiliensis, and Theiler's murine encephalomyelitis virus, and they made overtly normal Ab responses to a variety of antigens. Thus, CD134 is not essential for many T cell responses in vivo, nor is it required for the provision of help to B cells. Nonetheless, a subtle role in the regulation of T cell reactivity is suggested by the effect of CD134 deficiency on in vitro T cell responses.