Alzheimer Disease and Behavioral Variant Frontotemporal Dementia: Automatic Classification Based on Cortical Atrophy for Single-Subject Diagnosis

• Published in: Radiology Vol. 279; no. 3; pp. 838 - 848
• Main Authors: Möller, Christiane, Pijnenburg, Yolande A. L., van der Flier, Wiesje M., Versteeg, Adriaan, Tijms, Betty, de Munck, Jan C., Hafkemeijer, Anne, Rombouts, Serge A. R. B., van der Grond, Jeroen, van Swieten, John, Dopper, Elise, Scheltens, Philip, Barkhof, Frederik, Vrenken, Hugo, Wink, Alle Meije
• Format: Journal Article
• Language: English
• Published: United States 01.06.2016
• Subjects: Alzheimer Disease - classification; Alzheimer Disease - pathology; Atrophy; Diagnosis, Differential; Female; Frontotemporal Dementia - classification; Frontotemporal Dementia - pathology; Gray Matter - pathology; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; ROC Curve; Support Vector Machine

Purpose To investigate the diagnostic accuracy of an image-based classifier to distinguish between Alzheimer disease (AD) and behavioral variant frontotemporal dementia (bvFTD) in individual patients by using gray matter (GM) density maps computed from standard T1-weighted structural images obtained...