Transfer Elastic Net for Developing Epigenetic Clocks for the Japanese Population

• Published in: Mathematics (Basel) Vol. 12; no. 17; p. 2716
• Main Authors: Tomo, Yui, Nakaki, Ryo
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.09.2024
• Subjects: Age; Aging; biological age; Clocks; Cost analysis; Data analysis; Deoxyribonucleic acid; DNA; DNA methylation; Elastic analysis; Epigenetics; Parameter estimation; Principal components analysis; Regression models; Regularization methods; sparse regularization; Sparsity; transfer learning; Variables

The epigenetic clock evaluates human biological age based on DNA methylation patterns. It takes the form of a regression model where the methylation ratio at CpG sites serves as the predictor and age as the response variable. Due to the large number of CpG sites and their correlation, Elastic Net is...