Release of iron from transferrin by phosphonocarboxylate and diphosphonate chelating agents

• Published in: Journal of inorganic biochemistry Vol. 98; no. 11; pp. 1824 - 1836
• Main Authors: Harris, Wesley R., Brook, Claire E., Spilling, Christopher D., Elleppan, Sampathkumar, Peng, Wang, Xin, Meiguo, Wyk, Jennifer Van
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2004
• Subjects: Carboxylic Acids - chemical synthesis; Carboxylic Acids - pharmacology; Chelating Agents - chemical synthesis; Chelating Agents - pharmacology; Diphosphonates - chemical synthesis; Diphosphonates - pharmacology; Half-Life; Iron; Iron - metabolism; Kinetics; Ligands; Phosphonic acids; Spectrophotometry; Transferrin; Transferrin - drug effects; Transferrin - metabolism; Transferrin; Iron; Kinetics; Phosphonic acids

The rates at which phosphonocarboxylate and diphosphonate ligands remove iron from the serum iron transport protein transferrin at 25 °C and pH 7.4 have been evaluated. These ligands show a combination of saturation and first-order kinetics with respect to the free ligand concentrations. The ability...