Improved conversion of methanol to single-cell protein by Methylophilus methylotrophus
The glutamate dehydrogenase gene of Escherichia coli has been cloned into broad host-range plasmids and can complement glutamate synthase mutants of Methylophilus methylotrophus. Assimilation of ammonia via glutamate dehydrogenase is more energy-efficient than via glutamate synthase, thus the recomb...
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| Published in | Nature (London) Vol. 287; no. 5781; p. 396 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
02.10.1980
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| Subjects | |
| Online Access | Get more information |
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| Abstract | The glutamate dehydrogenase gene of Escherichia coli has been cloned into broad host-range plasmids and can complement glutamate synthase mutants of Methylophilus methylotrophus. Assimilation of ammonia via glutamate dehydrogenase is more energy-efficient than via glutamate synthase, thus the recombinant organism converts more growth substrate, methanol, into cellular carbon. |
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| AbstractList | The glutamate dehydrogenase gene of Escherichia coli has been cloned into broad host-range plasmids and can complement glutamate synthase mutants of Methylophilus methylotrophus. Assimilation of ammonia via glutamate dehydrogenase is more energy-efficient than via glutamate synthase, thus the recombinant organism converts more growth substrate, methanol, into cellular carbon. |
| Author | Barth, P T Byrom, D Pioli, D Atherton, K T Dart, E C Worsey, M J Pioli, E M Senior, P J Powell, K Windass, J D |
| Author_xml | – sequence: 1 givenname: J D surname: Windass fullname: Windass, J D – sequence: 2 givenname: M J surname: Worsey fullname: Worsey, M J – sequence: 3 givenname: E M surname: Pioli fullname: Pioli, E M – sequence: 4 givenname: D surname: Pioli fullname: Pioli, D – sequence: 5 givenname: P T surname: Barth fullname: Barth, P T – sequence: 6 givenname: K T surname: Atherton fullname: Atherton, K T – sequence: 7 givenname: E C surname: Dart fullname: Dart, E C – sequence: 8 givenname: D surname: Byrom fullname: Byrom, D – sequence: 9 givenname: K surname: Powell fullname: Powell, K – sequence: 10 givenname: P J surname: Senior fullname: Senior, P J |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/6776410$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Adenosine Triphosphate - metabolism Ammonia - metabolism Bacterial Proteins - biosynthesis DNA, Recombinant Escherichia coli - enzymology Genetic Engineering - methods Glutamate Dehydrogenase - genetics Glutamate Synthase - metabolism Methanol - metabolism Methylococcaceae - enzymology Methylococcaceae - metabolism Plasmids |
| Title | Improved conversion of methanol to single-cell protein by Methylophilus methylotrophus |
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