Cannabinoid receptor agonist WIN55,212-2 and fatty acid amide hydrolase inhibitor URB597 may protect against cognitive impairment in rats of chronic cerebral hypoperfusion via PI3K/AKT signaling

• Published in: Behavioural brain research Vol. 313; pp. 334 - 344
• Main Authors: Su, Shao-Hua, Wang, Yue-Qing, Wu, Yi-Fang, Wang, Da-Peng, Lin, Qi, Hai, Jian
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.10.2016
• Subjects: Animals; Benzamides - pharmacology; Benzoxazines - pharmacology; Cannabinoid Receptor Agonists - pharmacology; Carbamates - pharmacology; Chronic cerebral hypoperfusion; Cognitive Dysfunction - drug therapy; Cognitive impairment; Endocannabinoid system; Fatty Acids - metabolism; Glycogen Synthase Kinase 3 - metabolism; Long-Term Potentiation - drug effects; Male; Maze Learning - physiology; Mixed Function Oxygenases - antagonists & inhibitors; Morpholines - pharmacology; Naphthalenes - pharmacology; Neuroprotective Agents - pharmacology; Phosphatidylinositol 3-Kinases - metabolism; PI3K/AKT signaling; Proto-Oncogene Proteins c-akt - metabolism; Rats, Sprague-Dawley; Receptors, Cannabinoid - drug effects; Signal Transduction - drug effects; Endocannabinoid system; Chronic cerebral hypoperfusion; PI3K/AKT signaling; Cognitive impairment

•WIN55,212-2 and URB597 protect neurons against cognitive impairment.•WIN55,212-2 and URB597 inhibited cognitive impairment via the PI3K/AKT pathway.•WIN55,212-2 and URB597 may be the potential agents for cognitive impairment. The present study further investigated the protective effects of cannabin...