(+/-)-6-ACETAMIDO-1,2-ANHYDRO-6-DEOXY-MYO-INOSITOL - A TIGHT-BINDING INHIBITOR AND PSEUDOSUBSTRATE FOR N-ACETYL-BETA-GLUCOSAMINIDASES

• Published in: Carbohydrate research Vol. 233; pp. 113 - 123
• Main Authors: LEGLER, G, BOLLHAGEN, R
• Format: Journal Article
• Language: English
• Published: AMSTERDAM Elsevier 02.09.1992
• Subjects: Biochemistry & Molecular Biology; Chemistry; Chemistry, Applied; Chemistry, Organic; Life Sciences & Biomedicine; Physical Sciences; Science & Technology; GLYCOSIDE SPLITTING ENZYMES; GLUCOSIDASE; MECHANISM; ACTIVE-SITE

A five-step procedure is described for the synthesis of the title compound (N-acetylconduramine B trans-epoxide, 14) from tetra-O-acetylconduritol B [(+/-)-(1,3/2,4)-1,2,3,4-tetra-0-acetyl-5-cyclohexene-1,2,3,4-tetrol]. Inhibition studies with N-acetyl-beta-glucosaminidases from bovine kidney, jack...