Novel organoselenides (NSAIDs-Se derivatives) protect against LPS-induced inflammation in microglia by targeting the NOX2/NLRP3 signaling pathway
[Display omitted] •NSAID selenocyanate derivatives were found to exhibit a neuroprotective effect.•1-39 and 1A-38 could significantly suppress NOX2 expression and ROS production.•There appeared to be a link between the NLRP3 signaling pathway and the neuroprotective effect of 1-39 and 1A-38.•NSAID s...
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Published in | International immunopharmacology Vol. 101; p. 108377 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Amsterdam
Elsevier B.V
01.12.2021
Elsevier BV |
Subjects | |
Online Access | Get full text |
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