Novel organoselenides (NSAIDs-Se derivatives) protect against LPS-induced inflammation in microglia by targeting the NOX2/NLRP3 signaling pathway

• Published in: International immunopharmacology Vol. 101; p. 108377
• Main Authors: Han, Yunsu, Lu, Yin, Li, Xin, Niu, Xiaoqi, Chang, Alan K., Yang, Zhe, Li, Xiaolong, He, Xianran, Bi, Xiuli
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.12.2021; Elsevier BV
• Subjects: Anti-inflammatory agents; BV2 microglia; Central nervous system; CYBB protein; Hybridization; IL-1β; Immune response; Immunosuppressive agents; Inflammation; Inflammatory response; Interleukin 18; Lipopolysaccharides; Macrophages; Microglia; Microglial cells; Neuro-inflammation; Neurodegenerative diseases; NLRP3; Nonsteroidal anti-inflammatory drugs; NOX2; Organoselenium compounds; Oxidative stress; Parenchyma; Proteins; Selenium compounds; Signal transduction; Signaling; Thioredoxin; Neuro-inflammation; AD; TRAF; Organoselenium compounds; CNS; IL-1β; MAPK; MyD88; LPS; DCFH-DA; ASC; IRAK; NF-κB; BV2 microglia; NSAIDs; ROS; NLRP3; TXNIP; iNOS; caspase-1; NOX2; ELISA

[Display omitted] •NSAID selenocyanate derivatives were found to exhibit a neuroprotective effect.•1-39 and 1A-38 could significantly suppress NOX2 expression and ROS production.•There appeared to be a link between the NLRP3 signaling pathway and the neuroprotective effect of 1-39 and 1A-38.•NSAID s...