Radiolabeling and Preliminary In Vivo Evaluation of the Candidate CCR2 Targeting PET Radioligand [11C]AZD2423

• Published in: Pharmaceuticals (Basel, Switzerland) Vol. 18; no. 2; p. 135
• Main Authors: Dahl, Kenneth, Johnström, Peter, Tóth, Miklós, Bolin, Martin, Varnäs, Katarina, Nakao, Ryuji, Takano, Akihiro, Khani Meynaq, Yasir, Bayrakdarian, Malken, Cselényi, Zsolt, Halldin, Christer, Farde, Lars, Schou, Magnus
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 21.01.2025; MDPI
• Subjects: Automation; Blood-brain barrier; Brain research; Carbon; carbonylation; Chemokine Receptor 2; Ligands; Permeability; PET imaging; radiochemistry; radiopharmaceutical; Visualization; Chemokine Receptor 2; PET imaging; carbonylation; radiochemistry; radiopharmaceutical

Background: AZD2423 is a high-affinity and selective negative allosteric modulator of the chemokine receptor type 2 (CCR2). This receptor plays important roles in the extravasation and transmigration of monocytes under inflammatory conditions. The aims of the current positron emission tomography (PE...