The Clinical Role of miRNAs in the Development and Treatment of Glioblastoma

• Published in: International journal of molecular sciences Vol. 26; no. 6; p. 2723
• Main Authors: Epistolio, Samantha, Spina, Paolo, Zaed, Ismail, Cardia, Andrea, Marchi, Francesco, Frattini, Milo
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 18.03.2025; MDPI
• Subjects: Adults; Animals; Biomarkers, Tumor - genetics; Brain cancer; Brain Neoplasms - genetics; Brain Neoplasms - pathology; Brain Neoplasms - therapy; Brain research; Brain tumors; Cancer therapies; Classification; Clinical outcomes; Clinical trials; DNA methylation; Gene amplification; Gene Expression Regulation, Neoplastic; Genes; Genetic transcription; Genomes; Glioblastoma - genetics; Glioblastoma - pathology; Glioblastoma - therapy; Glioblastoma multiforme; Glioma; Humans; Medical prognosis; MicroRNA; MicroRNAs - genetics; MicroRNAs - metabolism; Mutation; Patients; Pediatrics; Prognosis; Radiation therapy; Review; Tumors; TMZ; treatment; GBM; miRNAs; prognosis; survival

Glioblastoma multiforme (GBM) is the most common brain tumor and one of the most aggressive, with a median overall survival (OS) of only 15–18 months. These characteristics make it necessary to identify new targets for the improvement of prognosis and better prediction of response to therapies curre...