Patterns in genomic mutations among patients with early-onset colorectal cancer: an international, multicohort, observational study

• Published in: The lancet oncology Vol. 26; no. 8; pp. 1055 - 1066
• Main Authors: Li, Jinming, Pan, Yedong, Guo, Fanying, Wang, Changzheng, Liang, Lei, Li, Peilong, Liang, Wenjie, Lian, Peng, Chen, Yikuan, Yang, Yongzhi, Lin, Wanrun, Li, Xinxiang, Perea, José, Hendrickx, Wouter R L, Holowatyj, Andreana N, Guo, Xingyi, Du, Lutao, Sinicrope, Frank A, Ma, Yanlei
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2025; Elsevier Limited
• Subjects: Adenocarcinoma; Adenomatous polyposis coli; Adult; Age; Age of Onset; Aged; Biomarkers, Tumor - genetics; Cohort analysis; Cohort Studies; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - epidemiology; Colorectal Neoplasms - genetics; Colorectal Neoplasms - pathology; Datasets; Evidence; Exome Sequencing; Female; Gene frequency; Genes; Genomics; Hematology, Oncology, and Palliative Medicine; Humans; K-Ras protein; Male; Medical research; Middle Aged; Mutation; Netherlands - epidemiology; Observational studies; p53 Protein; Patients; Race; Regression analysis; Review boards; Sample size; Tumors; Whole genome sequencing; Netherlands

The increasing incidence of early-onset colorectal cancer (age <50 years; EOCRC) shows a dramatic growing trend globally, while late-onset colorectal cancer (LOCRC) is gradually decreasing. We aimed to characterise the distinct mutational landscape of EOCRC in an effort to inform age-specific cli...