Sapheno-Femoral Junction Pathology: Molecular Mechanism of Saphenous Vein Incompetence

• Published in: Clinical and applied thrombosis/hemostasis Vol. 10; no. 4; pp. 311 - 321
• Main Authors: Urbanek, Tomasz, Skop, Barbara, Ziaja, Krzysztof, Wilczok, Tadeusz, Wiaderkiewicz, Ryszard, Pal/asz, Artur, Mazurek, Urszula, Wielgus, Ewa
• Format: Journal Article
• Language: English
• Published: Thousand Oaks, CA SAGE Publications 01.10.2004; SAGE PUBLICATIONS, INC
• Subjects: Adult; Aged; Apoptosis; Case-Control Studies; Cell cycle; Cell Cycle Proteins - analysis; Cell Cycle Proteins - genetics; Cyclin-Dependent Kinase Inhibitor p21; fas Receptor - analysis; fas Receptor - genetics; Female; Humans; Immunohistochemistry; Male; Middle Aged; Muscle, Smooth, Vascular - pathology; Proliferating Cell Nuclear Antigen - analysis; Proliferating Cell Nuclear Antigen - genetics; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - analysis; Saphenous Vein - chemistry; Saphenous Vein - pathology; Tissue Distribution; Tumor Suppressor Protein p53 - analysis; Tumor Suppressor Protein p53 - genetics; Varicose Veins - etiology; Vein valve; Saphenous vein; p21; Varicose veins

A molecular mechanism responsible for varicose vein occurrence was investigated. The role of potential cell cycle regulator p21 and programmed cell death in the pathology leading to the proximal long saphenous vein (LSV) incompetence was investigated. Proximal LSV specimens were obtained from 40 pat...