Role of vitamin B12 on methylmalonyl-CoA mutase activity

• Published in: Journal of Zhejiang University. B. Science Vol. 13; no. 6; pp. 423 - 437
• Main Author: Tóshiko TAKAHASHI-IIGUEZ Enrique GARCíA-HERNANDEZ Roberto ARREGUíN-ESPINOSA María Elena FLORES
• Format: Journal Article
• Language: English
• Published: Heidelberg SP Zhejiang University Press 01.06.2012; Zhejiang University Press
• Subjects: Amino Acid Metabolism, Inborn Errors - genetics; Amino Acid Metabolism, Inborn Errors - metabolism; Animals; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Biomedical and Life Sciences; Biomedicine; Biotechnology; Cobamides - metabolism; Humans; Mammals; Methylmalonyl-CoA Mutase - chemistry; Methylmalonyl-CoA Mutase - genetics; Methylmalonyl-CoA Mutase - metabolism; Mutant Proteins - genetics; Mutant Proteins - metabolism; Mutation; Propionibacterium - enzymology; Propionibacterium - genetics; Review; Vitamin B 12 - metabolism; Methylmalonyl-CoA mutase (MCM); Protectase; MMAA; Vitamin B; Reactivase; Q563+.4; MeaB; Methylmalonic academia (MMA)

Vitamin B 12 is an organometallic compound with important metabolic derivatives that act as cofactors of certain enzymes,which have been grouped into three subfamilies depending on their cofactors.Among them,methylmalonyl-CoA mutase （MCM） has been extensively studied.This enzyme catalyzes the revers...