Fasting plasma homocysteine as a sensitive parameter of antifolate effect: a study of psoriasis patients receiving low-dose methotrexate treatment

• Published in: Clinical pharmacology and therapeutics Vol. 46; no. 5; p. 510
• Main Authors: Refsum, H, Helland, S, Ueland, P M
• Format: Journal Article
• Language: English
• Published: United States 01.11.1989
• Subjects: Adult; Aged; Aged, 80 and over; Fasting; Female; Folic Acid Deficiency - blood; Folic Acid Deficiency - chemically induced; Homocysteine - blood; Humans; Male; Methionine - administration & dosage; Methotrexate - adverse effects; Methotrexate - therapeutic use; Middle Aged; Psoriasis - blood; Psoriasis - drug therapy; Regression Analysis

We have investigated the effect of low-dose methotrexate (25 mg weekly) on plasma homocysteine in 13 patients who had psoriasis. Total, free, and protein-bound homocysteine were determined both during fasting and after methionine loading. Psoriasis patients had significantly higher basal plasma homo...