NaV1.1 is essential for proprioceptive signaling and motor behaviors

• Published in: eLife Vol. 11
• Main Authors: Espino, Cyrrus M, Lewis, Cheyanne M, Ortiz, Serena, Dalal, Miloni S, Garlapalli, Snigdha, Wells, Kaylee M, O'Neil, Darik A, Wilkinson, Katherine A, Griffith, Theanne N
• Format: Journal Article
• Language: English
• Published: Cambridge eLife Sciences Publications Ltd 24.10.2022; eLife Sciences Publications, Ltd
• Subjects: Action potential; Ataxia; Behavior; Central nervous system; Channel gating; Coordination; electrophysiology; Excitability; Haploinsufficiency; Isoforms; motor function; Nav1.1; Nervous system; Neurological diseases; Neurons; Neuroscience; Pain; Peptides; Proprioception; Proprioceptors; Sensory neurons; Sodium; Sodium channels (voltage-gated); somatosensation; Statistical significance; Vibrations; voltage-gated sodium channel

The voltage-gated sodium channel (Na V ), Na V 1.1, is well-studied in the central nervous system; conversely, its contribution to peripheral sensory neuron function is more enigmatic. Here, we identify a new role for Na V 1.1 in mammalian proprioception. RNAscope analysis and in vitro patch-clamp r...