Diagnostic and clinical importance of interleukin-2 receptor alpha chain expression on non-T-cell acute leukaemia cells

• Published in: British journal of haematology Vol. 80; no. 3; p. 317
• Main Authors: Nakase, K, Kita, K, Otsuji, A, Anazawa, H, Hoshino, K, Sekine, T, Shirakawa, S, Tanaka, I, Nasu, K, Tsutani, H
• Format: Journal Article
• Language: English
• Published: England 01.03.1992
• Subjects: Acute Disease; Adolescent; Adult; Genotype; Humans; Leukemia - drug therapy; Leukemia - immunology; Leukemia - mortality; Leukemia, Myeloid - immunology; Myelodysplastic Syndromes - immunology; Phenotype; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - immunology; Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology; Prognosis; Receptors, Interleukin-2 - immunology; T-Lymphocytes - immunology
• ISSN: 0007-1048; 1365-2141
• DOI: 10.1111/j.1365-2141.1992.tb08139.x

The expression of interleukin-2 receptors (IL-2R) was examined in 328 adult patients with non-T-cell (non-T) acute leukaemia and blast crisis of chronic myelocytic leukaemia (CML.BC) using two monoclonal antibodies, anti-Tac for IL-2R alpha chain (IL-2R alpha) and Mik beta 1 for IL-2R beta chain (IL-2R beta). Leukaemic cells in the following cases were positive for anti-Tac; 28/192 of acute myelocytic leukaemia (AML), 24/44 CML-BC, 4/28 CD19(+)CD10(-) acute lymphoblastic leukaemia (ALL), and 20/64 common ALL (c-ALL). IL-2R beta was not detected on leukaemic cells of any case examined. Eleven of IL-2R alpha(+) AML were derived from myelodysplastic syndrome. None of the IL-2R alpha positive leukaemic cells responded to exogenous recombinant human IL-2 (rhIL-2) in culture. In addition, IL-2R alpha expression on non-T leukaemic cells was closely correlated with coexpressing different lineage markers and the presence of the Philadelphia abnormality. Marked increase of serum soluble IL-2R alpha was demonstrated in the IL-2R alpha(+) patients examined. Clinically, the IL-2R alpha(+) patients showed significantly lower response to chemotherapy and poorer prognosis than IL-2R alpha(-) patients. Our results clearly indicate the diagnostic importance of IL-2R alpha expression in non-T acute leukaemia with a close relation to the particular cellular characteristics and the prognosis.