Assessment of homocysteine status
Plasma total homocysteine (tHcy) determination is used in the diagnosis of homocystinuria, in cobalamin and folate deficiency and in cardiovascular risk assessment. However, determination of tHcy includes many pitfalls which complicate the assessment of homocysteine status. In the present article, w...
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| Published in | Journal of inherited metabolic disease Vol. 20; no. 2; pp. 286 - 294 |
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| Main Authors | , , , |
| Format | Journal Article Conference Proceeding |
| Language | English |
| Published |
Dordrecht
Kluwer Academic Publishers
01.06.1997
Springer |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Plasma total homocysteine (tHcy) determination is used in the diagnosis of homocystinuria, in cobalamin and folate deficiency and in cardiovascular risk assessment. However, determination of tHcy includes many pitfalls which complicate the assessment of homocysteine status. In the present article, we review basic knowledge for a rational use of plasma tHcy in diagnostic as well as scientific work. The subjects dealt with are procedures for sample handling and processing, the principles of tHcy analyses, and genetic and acquired determinants of the plasma tHcy concentration. |
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| AbstractList | Abstract
Plasma total homocysteine (tHcy) determination is used in the diagnosis of homocystinuria, in cobalamin and folate deficiency and in cardiovascular risk assessment. However, determination of tHcy includes many pitfalls which complicate the assessment of homocysteine status. In the present article, we review basic knowledge for a rational use of plasma tHcy in diagnostic as well as scientific work. The subjects dealt with are procedures for sample handling and processing, the principles of tHcy analyses, and genetic and acquired determinants of the plasma tHcy concentration. Plasma total homocysteine (tHcy) determination is used in the diagnosis of homocystinuria, in cobalamin and folate deficiency and in cardiovascular risk assessment. However, determination of tHcy includes many pitfalls which complicate the assessment of homocysteine status. In the present article, we review basic knowledge for a rational use of plasma tHcy in diagnostic as well as scientific work. The subjects dealt with are procedures for sample handling and processing, the principles of tHcy analyses, and genetic and acquired determinants of the plasma tHcy concentration. |
| Author | Guttormsen, A. B. Ueland, P. M. Refsum, H. Fiskerstrand, T. |
| Author_xml | – sequence: 1 givenname: H. surname: Refsum fullname: Refsum, H. organization: University of Bergen – sequence: 2 givenname: T. surname: Fiskerstrand fullname: Fiskerstrand, T. organization: University of Bergen – sequence: 3 givenname: A. B. surname: Guttormsen fullname: Guttormsen, A. B. organization: University of Bergen – sequence: 4 givenname: P. M. surname: Ueland fullname: Ueland, P. M. organization: University of Bergen |
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| Snippet | Plasma total homocysteine (tHcy) determination is used in the diagnosis of homocystinuria, in cobalamin and folate deficiency and in cardiovascular risk... Abstract Plasma total homocysteine (tHcy) determination is used in the diagnosis of homocystinuria, in cobalamin and folate deficiency and in cardiovascular... |
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| SubjectTerms | Aminoacid disorders Animals Biological and medical sciences Errors of metabolism Homocysteine - blood Humans Medical sciences Metabolic diseases Methionine - metabolism Specimen Handling |
| Title | Assessment of homocysteine status |
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