Assessment of homocysteine status

Plasma total homocysteine (tHcy) determination is used in the diagnosis of homocystinuria, in cobalamin and folate deficiency and in cardiovascular risk assessment. However, determination of tHcy includes many pitfalls which complicate the assessment of homocysteine status. In the present article, w...

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Bibliographic Details
Published inJournal of inherited metabolic disease Vol. 20; no. 2; pp. 286 - 294
Main Authors Refsum, H., Fiskerstrand, T., Guttormsen, A. B., Ueland, P. M.
Format Journal Article Conference Proceeding
LanguageEnglish
Published Dordrecht Kluwer Academic Publishers 01.06.1997
Springer
Subjects
Aminoacid disorders
Animals
Biological and medical sciences
Errors of metabolism
Homocysteine - blood
Humans
Medical sciences
Metabolic diseases
Methionine - metabolism
Specimen Handling
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Summary:Plasma total homocysteine (tHcy) determination is used in the diagnosis of homocystinuria, in cobalamin and folate deficiency and in cardiovascular risk assessment. However, determination of tHcy includes many pitfalls which complicate the assessment of homocysteine status. In the present article, we review basic knowledge for a rational use of plasma tHcy in diagnostic as well as scientific work. The subjects dealt with are procedures for sample handling and processing, the principles of tHcy analyses, and genetic and acquired determinants of the plasma tHcy concentration.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0141-8955
1573-2665
DOI:10.1023/A:1005321225893