Gi-mediated stimulation of type II adenylyl cyclase is augmented by Gq- coupled receptor activation and phorbol ester treatment

• Published in: The Journal of neuroscience Vol. 16; no. 4; pp. 1317 - 1323
• Main Authors: Tsu, RC, Wong, YH
• Format: Journal Article
• Language: English
• Published: United States Soc Neuroscience 15.02.1996; Society for Neuroscience
• Subjects: Adenylyl Cyclases - drug effects; Cell Line; Cyclic AMP - metabolism; Dopamine - metabolism; GTP-Binding Proteins - physiology; Humans; Models, Molecular; Phorbol Esters - pharmacology; Signal Transduction - drug effects

Synergism between Gs- and Gi- or Gq-dependent signaling pathways has been demonstrated in the stimulation of type II adenylyl cyclase (AC-II). Provision of activated alpha s is known to allow numerous Gi-coupled receptors to stimulate AC-II and to potentiate the responses to Gq-coupled receptors. To...