Vascular Damages in Rats Immunized by α1-Adrenoceptor Peptides

• Published in: Cellular & molecular immunology Vol. 5; no. 5; pp. 349 - 356
• Main Authors: Zhou, Zihua, Liao, Yuhua, Li, Liudong, Wei, Fen, Wang, Bin, Wei, Yumiao, Wang, Min, Cheng, Xiang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.10.2008; Nature Publishing Group; Institute of Cardiology,Union Hospital,Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430022,China
• Subjects: Adrenergic receptors; Antibodies; Arteries; Autoantibodies; Biomedical and Life Sciences; Biomedicine; Blood pressure; c-Fos protein; c-Jun protein; Collagen; Hyperplasia; Hypertension; Immunology; Medical Microbiology; Microbiology; Mitochondria; Norepinephrine; Peptides; Smooth muscle; Transcription factors; Vaccine; 缩氨酸; 自体抗体; 血管损害; 血管重建; α; adrenoceptor; autoantibody; vascular remodeling; α1-adrenoceptor

Autoantibodies against the α1-adrenoceptor which had agonist activity as norepinephrine might play roles in the progression of hypertension, but whether the autoantibodies could induce vascular remodeling as norepinephrine is not clear. In this paper, the models with antibodies against the α1-adreno...