The c‐Rel subunit of nuclear factor‐κB regulates murine liver inflammation, wound‐healing, and hepatocyte proliferation

• Published in: Hepatology (Baltimore, Md.) Vol. 51; no. 3; pp. 922 - 931
• Main Authors: Gieling, Roben G., Elsharkawy, Ahmed M., Caamaño, Jorge H., Cowie, David E., Wright, Matthew C., Ebrahimkhani, Mohammad R., Burt, Alastair D., Mann, Jelena, Raychaudhuri, Pradip, Liou, Hsiou‐Chi, Oakley, Fiona, Mann, Derek A.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.03.2010; Wiley
• Subjects: Biological and medical sciences; Gastroenterology. Liver. Pancreas. Abdomen; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Medical sciences; Liver; Rodentia; Inflammation; Subunit; Wound; Vertebrata; Regulation(control); Mammalia; Hepatocyte; Mouse; Animal; Gastroenterology; Transcription factor NFκB; Cicatrization

In this study, we determined the role of the nuclear factor‐kappaB (NF‐κB) subunit c‐Rel in liver injury and regeneration. In response to toxic injury of the liver, c‐Rel null (c‐rel−/−) mice displayed a defect in the neutrophilic inflammatory response, associated with impaired induction of RANTES (...