Xenon ventilation computed tomography and the management of asthma in the elderly
Background and objective Xenon ventilation computed tomography (CT) has shown potential in assessing the regional ventilation status in subjects with asthma. The purpose of this study was to evaluate the usefulness of xenon ventilation CT in the management of asthma in the elderly. Methods Treatment...
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Published in | Respirology (Carlton, Vic.) Vol. 19; no. 3; pp. 389 - 395 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
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Australia
Blackwell Publishing Ltd
01.04.2014
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Abstract | Background and objective
Xenon ventilation computed tomography (CT) has shown potential in assessing the regional ventilation status in subjects with asthma. The purpose of this study was to evaluate the usefulness of xenon ventilation CT in the management of asthma in the elderly.
Methods
Treatment‐naïve asthmatics aged 65 years or older were recruited. Before initiation of medication, spirometry with bronchodilator (BD) reversibility, questionnaires to assess the severity of symptoms including a visual analogue scale (VAS), tests to evaluate cognitive function and mood, and xenon ventilation CT were performed. Xenon gas trapping (XT) on xenon ventilation CT represents an area where inhaled xenon gas was not expired and was trapped. Symptoms and lung functions were measured again after the 12‐week treatment.
Results
A total of 30 elderly asthmatics were enrolled. The severity of dyspnoea measured by the VAS showed a significant correlation with the total number of areas of XT on the xenon ventilation CT taken in the pre‐BD wash‐out phase (r = −0.723, P < 0.001). The total number of areas of XT significantly decreased after BD inhalation, and differences in the total number of areas of XT (between the pre‐ and post‐BD wash‐out phases) at baseline showed significant correlations with the per cent increases in forced expiratory volume in 1 s after subsequent anti‐asthma treatment (r = −0.775, P < 0.001).
Conclusions
Xenon ventilation CT may be an objective and promising tool in the measurement of dyspnoea and prediction of the treatment response in elderly asthmatics.
The present study using xenon ventilation CT, which enabled us to measure the ventilation status objectively, showed that dyspnoea and treatment response in elderly asthmatics were significantly correlated with the status of xenon gas trapping. |
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AbstractList | Abstract
Background and objective
Xenon ventilation computed tomography (
CT
) has shown potential in assessing the regional ventilation status in subjects with asthma. The purpose of this study was to evaluate the usefulness of xenon ventilation
CT
in the management of asthma in the elderly.
Methods
Treatment‐naïve asthmatics aged 65 years or older were recruited. Before initiation of medication, spirometry with bronchodilator (
BD
) reversibility, questionnaires to assess the severity of symptoms including a visual analogue scale (
VAS
), tests to evaluate cognitive function and mood, and xenon ventilation
CT
were performed. Xenon gas trapping (
XT
) on xenon ventilation
CT
represents an area where inhaled xenon gas was not expired and was trapped. Symptoms and lung functions were measured again after the 12‐week treatment.
Results
A total of 30 elderly asthmatics were enrolled. The severity of dyspnoea measured by the
VAS
showed a significant correlation with the total number of areas of
XT
on the xenon ventilation
CT
taken in the pre‐
BD
wash‐out phase (
r
= −0.723,
P
< 0.001). The total number of areas of
XT
significantly decreased after
BD
inhalation, and differences in the total number of areas of
XT
(between the pre‐ and post‐
BD
wash‐out phases) at baseline showed significant correlations with the per cent increases in forced expiratory volume in 1 s after subsequent anti‐asthma treatment (
r
= −0.775,
P
< 0.001).
Conclusions
Xenon ventilation
CT
may be an objective and promising tool in the measurement of dyspnoea and prediction of the treatment response in elderly asthmatics.
The present study using xenon ventilation CT, which enabled us to measure the ventilation status objectively, showed that dyspnoea and treatment response in elderly asthmatics were significantly correlated with the status of xenon gas trapping. Xenon ventilation computed tomography (CT) has shown potential in assessing the regional ventilation status in subjects with asthma. The purpose of this study was to evaluate the usefulness of xenon ventilation CT in the management of asthma in the elderly. Treatment-naïve asthmatics aged 65 years or older were recruited. Before initiation of medication, spirometry with bronchodilator (BD) reversibility, questionnaires to assess the severity of symptoms including a visual analogue scale (VAS), tests to evaluate cognitive function and mood, and xenon ventilation CT were performed. Xenon gas trapping (XT) on xenon ventilation CT represents an area where inhaled xenon gas was not expired and was trapped. Symptoms and lung functions were measured again after the 12-week treatment. A total of 30 elderly asthmatics were enrolled. The severity of dyspnoea measured by the VAS showed a significant correlation with the total number of areas of XT on the xenon ventilation CT taken in the pre-BD wash-out phase (r = -0.723, P < 0.001). The total number of areas of XT significantly decreased after BD inhalation, and differences in the total number of areas of XT (between the pre- and post-BD wash-out phases) at baseline showed significant correlations with the per cent increases in forced expiratory volume in 1 s after subsequent anti-asthma treatment (r = -0.775, P < 0.001). Xenon ventilation CT may be an objective and promising tool in the measurement of dyspnoea and prediction of the treatment response in elderly asthmatics. BACKGROUND AND OBJECTIVEXenon ventilation computed tomography (CT) has shown potential in assessing the regional ventilation status in subjects with asthma. The purpose of this study was to evaluate the usefulness of xenon ventilation CT in the management of asthma in the elderly.METHODSTreatment-naïve asthmatics aged 65 years or older were recruited. Before initiation of medication, spirometry with bronchodilator (BD) reversibility, questionnaires to assess the severity of symptoms including a visual analogue scale (VAS), tests to evaluate cognitive function and mood, and xenon ventilation CT were performed. Xenon gas trapping (XT) on xenon ventilation CT represents an area where inhaled xenon gas was not expired and was trapped. Symptoms and lung functions were measured again after the 12-week treatment.RESULTSA total of 30 elderly asthmatics were enrolled. The severity of dyspnoea measured by the VAS showed a significant correlation with the total number of areas of XT on the xenon ventilation CT taken in the pre-BD wash-out phase (r = -0.723, P < 0.001). The total number of areas of XT significantly decreased after BD inhalation, and differences in the total number of areas of XT (between the pre- and post-BD wash-out phases) at baseline showed significant correlations with the per cent increases in forced expiratory volume in 1 s after subsequent anti-asthma treatment (r = -0.775, P < 0.001).CONCLUSIONSXenon ventilation CT may be an objective and promising tool in the measurement of dyspnoea and prediction of the treatment response in elderly asthmatics. Background and objective Xenon ventilation computed tomography (CT) has shown potential in assessing the regional ventilation status in subjects with asthma. The purpose of this study was to evaluate the usefulness of xenon ventilation CT in the management of asthma in the elderly. Methods Treatment‐naïve asthmatics aged 65 years or older were recruited. Before initiation of medication, spirometry with bronchodilator (BD) reversibility, questionnaires to assess the severity of symptoms including a visual analogue scale (VAS), tests to evaluate cognitive function and mood, and xenon ventilation CT were performed. Xenon gas trapping (XT) on xenon ventilation CT represents an area where inhaled xenon gas was not expired and was trapped. Symptoms and lung functions were measured again after the 12‐week treatment. Results A total of 30 elderly asthmatics were enrolled. The severity of dyspnoea measured by the VAS showed a significant correlation with the total number of areas of XT on the xenon ventilation CT taken in the pre‐BD wash‐out phase (r = −0.723, P < 0.001). The total number of areas of XT significantly decreased after BD inhalation, and differences in the total number of areas of XT (between the pre‐ and post‐BD wash‐out phases) at baseline showed significant correlations with the per cent increases in forced expiratory volume in 1 s after subsequent anti‐asthma treatment (r = −0.775, P < 0.001). Conclusions Xenon ventilation CT may be an objective and promising tool in the measurement of dyspnoea and prediction of the treatment response in elderly asthmatics. The present study using xenon ventilation CT, which enabled us to measure the ventilation status objectively, showed that dyspnoea and treatment response in elderly asthmatics were significantly correlated with the status of xenon gas trapping. |
Author | Kim, Tae-Wan Jung, Jae-Woo Kim, Kyung-Mook Goo, Jin Mo Lee, Chang Hyun Park, Heung-Woo Min, Kyung-Up Lee, So-Hee Cho, Sang-Heon |
Author_xml | – sequence: 1 givenname: Heung-Woo surname: Park fullname: Park, Heung-Woo organization: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea – sequence: 2 givenname: Jae-Woo surname: Jung fullname: Jung, Jae-Woo organization: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea – sequence: 3 givenname: Kyung-Mook surname: Kim fullname: Kim, Kyung-Mook organization: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea – sequence: 4 givenname: Tae-Wan surname: Kim fullname: Kim, Tae-Wan organization: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea – sequence: 5 givenname: So-Hee surname: Lee fullname: Lee, So-Hee organization: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea – sequence: 6 givenname: Chang Hyun surname: Lee fullname: Lee, Chang Hyun organization: Department of Radiology, Seoul National University College of Medicine, Seoul, Korea – sequence: 7 givenname: Jin Mo surname: Goo fullname: Goo, Jin Mo organization: Department of Radiology, Seoul National University College of Medicine, Seoul, Korea – sequence: 8 givenname: Kyung-Up surname: Min fullname: Min, Kyung-Up organization: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea – sequence: 9 givenname: Sang-Heon surname: Cho fullname: Cho, Sang-Heon email: shcho@snu.ac.kr organization: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24512222$$D View this record in MEDLINE/PubMed |
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CitedBy_id | crossref_primary_10_1016_j_rmed_2023_107130 crossref_primary_10_1111_resp_12488 crossref_primary_10_3390_diagnostics13152518 crossref_primary_10_1002_jmri_25010 crossref_primary_10_1016_j_ejrad_2016_10_035 crossref_primary_10_1016_j_ejrad_2016_11_010 crossref_primary_10_1097_MD_0000000000005937 crossref_primary_10_1038_s12276_018_0110_5 crossref_primary_10_2214_AJR_17_18709 crossref_primary_10_4168_aair_2023_15_1_8 |
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Copyright | 2014 The Authors. Respirology © 2014 Asian Pacific Society of Respirology 2014 The Authors. Respirology © 2014 Asian Pacific Society of Respirology. |
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Notes | Figure S1 Correlations between the total number of areas of ventilation defect and the total number of areas of xenon gas trapping on xenon ventilation CT before bronchodilator inhalation. Figure S2 Correlations between baseline LNPC20 and % increase in FEV1 after 12-week anti-asthma treatment. Figure S3 Correlations between decreases in the total number of areas of xenon gas trapping after BD inhalation at baseline and increases in VAS, SSc, and QOL after 12-week anti-asthma treatment. Figure S4 Correlations between the total number areas of ventilation defect in the pre- and the post-BD WI phase and changes after BD inhalation at baseline and percent increases in FEV1 after 12-week anti-asthma treatment. Appendix S1 Detailed methods. ark:/67375/WNG-M23SKVV1-M Korea Centers for Disease Control and Prevention - No. 2009-E33022-00 ArticleID:RESP12242 istex:02074BBEDCF7A34C3BD7ECF031478CA8AB66D764 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
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Xenon ventilation computed tomography (CT) has shown potential in assessing the regional ventilation status in subjects with asthma.... Xenon ventilation computed tomography (CT) has shown potential in assessing the regional ventilation status in subjects with asthma. The purpose of this study... Abstract Background and objective Xenon ventilation computed tomography ( CT ) has shown potential in assessing the regional ventilation status in subjects... BACKGROUND AND OBJECTIVEXenon ventilation computed tomography (CT) has shown potential in assessing the regional ventilation status in subjects with asthma.... |
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SubjectTerms | Aged Aged, 80 and over asthma Asthma - diagnostic imaging Disability Evaluation Dyspnea - diagnostic imaging dyspnoea elderly Female Humans Male Pulmonary Ventilation Spirometry Surveys and Questionnaires Tomography, X-Ray Computed - methods treatment response Xenon xenon ventilation computed tomography |
Title | Xenon ventilation computed tomography and the management of asthma in the elderly |
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