Dose effects of alfentanil in human analgesia

• Published in: Clinical pharmacology and therapeutics Vol. 40; no. 2; p. 178
• Main Authors: Hill, H, Walter, M H, Saeger, L, Sargur, M, Sizemore, W, Chapman, C R
• Format: Journal Article
• Language: English
• Published: United States 01.08.1986
• Subjects: Adult; Alfentanil; Analgesia; Dose-Response Relationship, Drug; Evoked Potentials; Fentanyl - analogs & derivatives; Fentanyl - metabolism; Half-Life; Humans; In Vitro Techniques; Injections, Intravenous; Kinetics; Male; Pain

Alfentanil, a rapidly acting opioid, was given in subanesthetic doses to 10 subjects in a laboratory setting. Analgesia was assessed from the subjects' responses to painful dental stimulation. A subjective pain report (PR) and brain evoked potential (EP) amplitude were obtained repeatedly befor...