Obesity and kidney disease

Obesity has been pointed out as an important cause of kidney diseases. Due to its close association with diabetes and hypertension, excess weight and obesity are important risk factors for chronic kidney disease (CKD). Obesity influences CKD development, among other factors, because it predisposes t...

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Published inBrazilian Journal of Nephrology Vol. 39; no. 1; pp. 65 - 69
Main Authors Silva Junior, Geraldo Bezerra da, Bentes, Ana Carla Sobral Novaes, Daher, Elizabeth De Francesco, Matos, Sheila Maria Alvim de
Format Journal Article
LanguagePortuguese
English
Published Brazil Sociedade Brasileira de Nefrologia 01.03.2017
Subjects
Humans
kidney failure, chronic
obesity
Obesity - complications
Obesity - metabolism
Obesity - physiopathology
overweight
Renal Insufficiency, Chronic - etiology
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Abstract Obesity has been pointed out as an important cause of kidney diseases. Due to its close association with diabetes and hypertension, excess weight and obesity are important risk factors for chronic kidney disease (CKD). Obesity influences CKD development, among other factors, because it predisposes to diabetic nephropathy, hypertensive nephrosclerosis and focal and segmental glomerulosclerosis. Excess weight and obesity are associated with hemodynamic, structural and histological renal changes, in addition to metabolic and biochemical alterations that lead to kidney disease. Adipose tissue is dynamic and it is involved in the production of "adipokines", such as leptin, adiponectin, tumor necrosis factor-α, monocyte chemoattractant protein-1, transforming growth factor-β and angiotensin-II. A series of events is triggered by obesity, including insulin resistance, glucose intolerance, dyslipidemia, atherosclerosis and hypertension. There is evidence that obesity itself can lead to kidney disease development. Further studies are required to better understand the association between obesity and kidney disease.
AbstractList Abstract Obesity has been pointed out as an important cause of kidney diseases. Due to its close association with diabetes and hypertension, excess weight and obesity are important risk factors for chronic kidney disease (CKD). Obesity influences CKD development, among other factors, because it predisposes to diabetic nephropathy, hypertensive nephrosclerosis and focal and segmental glomerulosclerosis. Excess weight and obesity are associated with hemodynamic, structural and histological renal changes, in addition to metabolic and biochemical alterations that lead to kidney disease. Adipose tissue is dynamic and it is involved in the production of "adipokines", such as leptin, adiponectin, tumor necrosis factor-α, monocyte chemoattractant protein-1, transforming growth factor-β and angiotensin-II. A series of events is triggered by obesity, including insulin resistance, glucose intolerance, dyslipidemia, atherosclerosis and hypertension. There is evidence that obesity itself can lead to kidney disease development. Further studies are required to better understand the association between obesity and kidney disease.
Obesity has been pointed out as an important cause of kidney diseases. Due to its close association with diabetes and hypertension, excess weight and obesity are important risk factors for chronic kidney disease (CKD). Obesity influences CKD development, among other factors, because it predisposes to diabetic nephropathy, hypertensive nephrosclerosis and focal and segmental glomerulosclerosis. Excess weight and obesity are associated with hemodynamic, structural and histological renal changes, in addition to metabolic and biochemical alterations that lead to kidney disease. Adipose tissue is dynamic and it is involved in the production of "adipokines", such as leptin, adiponectin, tumor necrosis factor-α, monocyte chemoattractant protein-1, transforming growth factor-β and angiotensin-II. A series of events is triggered by obesity, including insulin resistance, glucose intolerance, dyslipidemia, atherosclerosis and hypertension. There is evidence that obesity itself can lead to kidney disease development. Further studies are required to better understand the association between obesity and kidney disease.
Author Bentes, Ana Carla Sobral Novaes
Silva Junior, Geraldo Bezerra da
Daher, Elizabeth De Francesco
Matos, Sheila Maria Alvim de
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  surname: Silva Junior
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  givenname: Ana Carla Sobral Novaes
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  fullname: Bentes, Ana Carla Sobral Novaes
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  givenname: Elizabeth De Francesco
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  givenname: Sheila Maria Alvim de
  surname: Matos
  fullname: Matos, Sheila Maria Alvim de
  organization: Universidade Federal da Bahia, Brazil
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Snippet Obesity has been pointed out as an important cause of kidney diseases. Due to its close association with diabetes and hypertension, excess weight and obesity...
Abstract Obesity has been pointed out as an important cause of kidney diseases. Due to its close association with diabetes and hypertension, excess weight and...
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StartPage 65
SubjectTerms Humans
kidney failure, chronic
obesity
Obesity - complications
Obesity - metabolism
Obesity - physiopathology
overweight
Renal Insufficiency, Chronic - etiology
Title Obesity and kidney disease
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