The Role of the IL-12 polymorphism rs3212227 in preeclampsia in Chinese Han Women

Objective: To investigate whether IL-12B rs3212227 was associated with susceptibility to PE (preeclampsia) in Chinese Han women. Methods: We enrolled 1000 PE patients and 1287 controls and performed rs3212227 genotyping by PCR-restriction fragment length polymorphism. Results: No significant differe...

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Published inClinical and experimental hypertension (1993) Vol. 38; no. 4; pp. 388 - 392
Main Authors Wang, Xibing, Guo, Mingzhen, Li, Sai, Gong, Jianfeng, Song, Weiqing, Wang, Haiyan, Liu, Shiguo
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 18.05.2016
Subjects
Adult
Alleles
China - epidemiology
Female
Gene Frequency
Genetic Predisposition to Disease
Genetics
Genotype
Humans
IL-12
Interleukin-12 Subunit p40 - genetics
polymorphism
Polymorphism, Single Nucleotide
Pre-Eclampsia - epidemiology
Pre-Eclampsia - genetics
preeclampsia
Pregnancy
susceptibility
Genetics
polymorphism
susceptibility
preeclampsia
IL-12
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Abstract Objective: To investigate whether IL-12B rs3212227 was associated with susceptibility to PE (preeclampsia) in Chinese Han women. Methods: We enrolled 1000 PE patients and 1287 controls and performed rs3212227 genotyping by PCR-restriction fragment length polymorphism. Results: No significant differences in genetic distributions of IL-12B rs3212227 were observed between cases and controls (χ 2 = 4.62, p = 0.10 by genotype; χ 2 = 0.03, p = 0.87 by allele). There were also no significant differences in genotypic and allelic frequencies between mild/severe or early/late-onset PE and control subgroups. Conclusion: Our data suggested that IL-12B rs3212227 might not be a critical risk factor for PE in Chinese Han women.
AbstractList OBJECTIVETo investigate whether IL-12B rs3212227 was associated with susceptibility to PE (preeclampsia) in Chinese Han women.METHODSWe enrolled 1000 PE patients and 1287 controls and performed rs3212227 genotyping by PCR-restriction fragment length polymorphism.RESULTSNo significant differences in genetic distributions of IL-12B rs3212227 were observed between cases and controls (χ(2) = 4.62, p = 0.10 by genotype; χ(2) = 0.03, p = 0.87 by allele). There were also no significant differences in genotypic and allelic frequencies between mild/severe or early/late-onset PE and control subgroups.CONCLUSIONOur data suggested that IL-12B rs3212227 might not be a critical risk factor for PE in Chinese Han women.
Objective: To investigate whether IL-12B rs3212227 was associated with susceptibility to PE (preeclampsia) in Chinese Han women. Methods: We enrolled 1000 PE patients and 1287 controls and performed rs3212227 genotyping by PCR-restriction fragment length polymorphism. Results: No significant differences in genetic distributions of IL-12B rs3212227 were observed between cases and controls (χ 2 = 4.62, p = 0.10 by genotype; χ 2 = 0.03, p = 0.87 by allele). There were also no significant differences in genotypic and allelic frequencies between mild/severe or early/late-onset PE and control subgroups. Conclusion: Our data suggested that IL-12B rs3212227 might not be a critical risk factor for PE in Chinese Han women.
To investigate whether IL-12B rs3212227 was associated with susceptibility to PE (preeclampsia) in Chinese Han women. We enrolled 1000 PE patients and 1287 controls and performed rs3212227 genotyping by PCR-restriction fragment length polymorphism. No significant differences in genetic distributions of IL-12B rs3212227 were observed between cases and controls (χ(2) = 4.62, p = 0.10 by genotype; χ(2) = 0.03, p = 0.87 by allele). There were also no significant differences in genotypic and allelic frequencies between mild/severe or early/late-onset PE and control subgroups. Our data suggested that IL-12B rs3212227 might not be a critical risk factor for PE in Chinese Han women.
Author Wang, Xibing
Guo, Mingzhen
Song, Weiqing
Wang, Haiyan
Li, Sai
Liu, Shiguo
Gong, Jianfeng
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  organization: Obstetrical Department, Maternal and Child Health Care of Zaozhuang
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Snippet Objective: To investigate whether IL-12B rs3212227 was associated with susceptibility to PE (preeclampsia) in Chinese Han women. Methods: We enrolled 1000 PE...
To investigate whether IL-12B rs3212227 was associated with susceptibility to PE (preeclampsia) in Chinese Han women. We enrolled 1000 PE patients and 1287...
OBJECTIVETo investigate whether IL-12B rs3212227 was associated with susceptibility to PE (preeclampsia) in Chinese Han women.METHODSWe enrolled 1000 PE...
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SubjectTerms Adult
Alleles
China - epidemiology
Female
Gene Frequency
Genetic Predisposition to Disease
Genetics
Genotype
Humans
IL-12
Interleukin-12 Subunit p40 - genetics
polymorphism
Polymorphism, Single Nucleotide
Pre-Eclampsia - epidemiology
Pre-Eclampsia - genetics
preeclampsia
Pregnancy
susceptibility
Title The Role of the IL-12 polymorphism rs3212227 in preeclampsia in Chinese Han Women
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