Neurophysiological alterations during strategy-based verbal learning in traumatic brain injury

• Published in: Neurorehabilitation and neural repair Vol. 23; no. 3; p. 226
• Main Authors: Strangman, Gary E, Goldstein, Richard, O'Neil-Pirozzi, Therese M, Kelkar, Kalika, Supelana, Christina, Burke, David, Katz, Douglas I, Rauch, Scott L, Savage, Cary R, Glenn, Mel B
• Format: Journal Article
• Language: English
• Published: United States 01.03.2009
• Subjects: Adaptation, Physiological - physiology; Adult; Brain Injuries - complications; Brain Injuries - pathology; Brain Injuries - physiopathology; Brain Mapping; Female; Humans; Language Tests; Learning - physiology; Learning Disorders - etiology; Learning Disorders - pathology; Learning Disorders - physiopathology; Magnetic Resonance Imaging; Male; Middle Aged; Nerve Net - anatomy & histology; Nerve Net - physiology; Neuronal Plasticity - physiology; Neuropsychological Tests; Parietal Lobe - anatomy & histology; Parietal Lobe - physiology; Prefrontal Cortex - anatomy & histology; Prefrontal Cortex - physiology; Recovery of Function - physiology; Verbal Behavior - physiology

Verbal learning and strategic processing deficits are common sequelae of traumatic brain injury (TBI); however, the neurophysiological mechanisms underlying such deficits remain poorly understood. We performed functional magnetic resonance imaging (fMRI) in 25 individuals with chronic TBI (>1 yea...