Methamphetamine-induced adaptation of learning rate dynamics depend on baseline performance

• Published in: eLife Vol. 13
• Main Authors: Kirschner, Hans, Molla, Hanna M, Nassar, Matthew R, de Wit, Harriet, Ullsperger, Markus
• Format: Journal Article
• Language: English
• Published: England eLife Sciences Publications Ltd 21.07.2025; eLife Sciences Publications, Ltd
• Subjects: Adult; Blindness; Catecholamines; Central Nervous System Stimulants - administration & dosage; Central Nervous System Stimulants - pharmacology; computational neuroscience; Dopamine; Double-Blind Method; Drugs; Female; Flexibility; Humans; learning; Learning - drug effects; Male; Methamphetamine; Methamphetamine - administration & dosage; Methamphetamine - pharmacology; Neuroscience; Reversal learning; Reversal Learning - drug effects; Young Adult; catecholamines; learning; computational neuroscience; human; neuroscience

The ability to calibrate learning according to new information is a fundamental component of an organism’s ability to adapt to changing conditions. Yet, the exact neural mechanisms guiding dynamic learning rate adjustments remain unclear. Catecholamines appear to play a critical role in adjusting th...