Is adiponectin involved in morphea pathogenesis? – first observational study

• Published in: Frontiers in immunology Vol. 16; p. 1588439
• Main Authors: Polańska, Adriana, Bratborska, Aleksandra Wiktoria, Kowalczyk, Michał J., Żaba, Ryszard, Dańczak-Pazdrowska, Aleksandra
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 2025
• Subjects: adiponectin; Adiponectin - blood; Adult; Biomarkers - blood; Case-Control Studies; connective tissue disease; Female; Humans; localized scleroderma; Male; Middle Aged; morphea; Scleroderma, Localized - blood; Scleroderma, Localized - diagnosis; Scleroderma, Localized - etiology; Scleroderma, Localized - pathology; Severity of Illness Index; Skin - pathology; skin fibrosis; skin sclerosis; Young Adult; fibroproliferative diseases; adiponectin; fibrosis biomarkers; localized scleroderma; skin fibrosis; morphea; skin sclerosis; connective tissue disease

Morphea is a chronic inflammatory condition characterized by fibrosis of the skin and/or subcutaneous tissues. Adiponectin is an adipokine known for its anti-inflammatory and antifibrotic properties. Lower levels of this protein have been associated with various diseases, but to date, no studies hav...