Improving regorafenib's organ target precision via nano-assembly to change its delivery mode abolishes chemoresistance and liver metastasis of colorectal cancer

• Published in: Journal of colloid and interface science Vol. 607; no. Pt 1; pp. 229 - 241
• Main Authors: Liu, Jia, Fu, Daan, Wang, Kang, Yuan, Ye, Deng, Yan, Shi, Lin, Li, Mingyi, Zhou, Cheng, Lu, Xiaohuan, Lv, Qiying, Wang, Guobin, Wang, Lin, Wang, Zheng
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.02.2022
• Subjects: Advanced colorectal cancer; bioavailability; blood circulation; colorectal neoplasms; Drug delivery; encapsulation; fluorescent dyes; hydrophobicity; intravenous injection; liver; metastasis; mortality; Nanodrug; Regorafenib; Self-assembly; Regorafenib; Self-assembly; Drug delivery; Nanodrug; Advanced colorectal cancer

A regorafenib nanodrug is prepared by self-assembly using regorafenib and clinically approved indocyanine green, which sufficiently delivers regorafenib into colorectal tumor and liver metastasis, markedly enhances regorafenib’s therapeutic efficacy. [Display omitted] •A regorafenib nanodrug (nanoRF...