Investigation of pharmaceuticals and illicit drugs in waters by liquid chromatography-high-resolution mass spectrometry

• Published in: TrAC, Trends in analytical chemistry (Regular ed.) Vol. 63; pp. 140 - 157
• Main Authors: Hernández, F., Ibáñez, M., Bade, R., Bijlsma, L., Sancho, J.V.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.12.2014
• Subjects: Emerging contaminant; High-resolution mass spectrometry (HRMS); Illicit drug; LC-HRMS; Liquid chromatography (LC); Orbitrap; Pharmaceutical; Screening; Time of flight; Transformation product; High-resolution mass spectrometry (HRMS); Screening; Emerging contaminant; Illicit drug; Liquid chromatography (LC); Time of flight; Orbitrap; Pharmaceutical; LC-HRMS; Transformation product

•Overview of LC-HRMS in investigating illicit drugs and pharmaceuticals in waters.•We consider time-of-flight (TOF) and Orbitrap mass analyzers.•We discuss the benefits of using UHPLC in combination with HRMS.•Target, suspect and non-target screening can be performed with the same instrument.•Retros...