Association of PEAR1 rs12041331 polymorphism and pharmacodynamics of ticagrelor in healthy Chinese volunteers

• Published in: Xenobiotica Vol. 47; no. 12; pp. 1130 - 1138
• Main Authors: Li, Mupeng, Hu, Yaodong, Wen, Zhipeng, Li, Huilan, Hu, Xiaolei, Zhang, Yanjiao, Zhang, Zanling, Xiao, Jian, Tang, Jie, Chen, Xiaoping
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 02.12.2017
• Subjects: Adenosine - analogs & derivatives; Adenosine - metabolism; Adenosine - pharmacokinetics; Adult; China; Healthy Volunteers; Humans; Male; Middle Aged; PEAR1; pharmacodynamics; pharmacokinetics; Polymorphism, Genetic; polymorphisms; Purinergic P2Y Receptor Antagonists - pharmacokinetics; Receptors, Cell Surface - genetics; ticagrelor; pharmacokinetics; ticagrelor; PEAR1; polymorphisms; pharmacodynamics

1. Genetic polymorphisms in platelet endothelial aggregation receptor 1 (PEAR1) were associated with responsiveness to aspirin and P2Y12 receptor antagonists. This study aimed to investigate whether PEAR1 polymorphism is associated with ticagrelor pharmacodynamics in healthy Chinese subjects. 2. The...