Modafinil Induces Wakefulness Without Intensifying Motor Activity or Subsequent Rebound Hypersomnolence in the Rat

• Published in: The Journal of pharmacology and experimental therapeutics Vol. 283; no. 2; pp. 757 - 769
• Main Authors: Edgar, Dale M., Seidel, Wesley F.
• Format: Journal Article
• Language: English
• Published: United States American Society for Pharmacology and Experimental Therapeutics 01.11.1997
• Subjects: Animals; Benzhydryl Compounds - pharmacology; Body Temperature - drug effects; Central Nervous System Stimulants - pharmacology; Electroencephalography - drug effects; Male; Methamphetamine - pharmacology; Motor Activity - drug effects; Rats; Rats, Wistar; Sleep, REM - drug effects; Wakefulness - drug effects

Modafinil, a novel compound for treating excessive sleepiness, potently increases wakefulness in laboratory rodents, cats, monkeys and humans. Although its mechanism of action is unknown, modafinil appears to be unlike classic stimulants. We investigated this generality by testing the selectivity of...