Prevalence and factors associated with gluten sensitivity in inflammatory bowel disease
Gluten sensitivity (GS) arises with celiac disease and has also been found in non-celiac disorders, although its characteristics in inflammatory bowel disease (IBD) are unclear. This study evaluated the prevalence of GS and factors associated with GS in IBD. Adult IBD patients at a tertiary-care med...
Saved in:
Published in | Scandinavian journal of gastroenterology p. 1 |
---|---|
Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
01.02.2018
|
Subjects | |
Online Access | Get more information |
Cover
Loading…
Abstract | Gluten sensitivity (GS) arises with celiac disease and has also been found in non-celiac disorders, although its characteristics in inflammatory bowel disease (IBD) are unclear. This study evaluated the prevalence of GS and factors associated with GS in IBD.
Adult IBD patients at a tertiary-care medical center completed a survey of their demographics, medical history, family history, social history and symptoms. Data on IBD characteristics were abstracted from the medical records. Descriptive analyses estimated the prevalence of GS. Multivariable logistic regression assessed the association between GS and patient or disease factors.
Of 102 IBD patients (55 Crohn's disease [CD], 46 ulcerative colitis [UC] and 3 IBD-unclassified), GS was reported in 23.6 and 27.3% of CD and UC patients, respectively. Common symptoms included fatigue, abdominal pain, diarrhea, bloating and hematochezia. There was no difference in these symptoms when comparing patients with and without GS. When evaluating IBD-related factors, GS was associated with having had a recent flare (adjusted odds ratio [aOR] 7.4; 95% confidence interval [CI] 1.6-34.1), stenotic disease in CD (aOR 4.7; 95% CI 1.1-20.2) and dermatologic manifestations (aOR 5.5; 95% CI 1.2-24.1).
GS was common in IBD and associated with having had a recent flare. GS may be transient for some patients, whereby dietary recommendations during and after a flare could focus on the avoidance of specific food triggers with possible reintroduction of these foods over time. This study prompts further prospective investigation into the temporal evolution of GS in IBD. |
---|---|
AbstractList | Gluten sensitivity (GS) arises with celiac disease and has also been found in non-celiac disorders, although its characteristics in inflammatory bowel disease (IBD) are unclear. This study evaluated the prevalence of GS and factors associated with GS in IBD.
Adult IBD patients at a tertiary-care medical center completed a survey of their demographics, medical history, family history, social history and symptoms. Data on IBD characteristics were abstracted from the medical records. Descriptive analyses estimated the prevalence of GS. Multivariable logistic regression assessed the association between GS and patient or disease factors.
Of 102 IBD patients (55 Crohn's disease [CD], 46 ulcerative colitis [UC] and 3 IBD-unclassified), GS was reported in 23.6 and 27.3% of CD and UC patients, respectively. Common symptoms included fatigue, abdominal pain, diarrhea, bloating and hematochezia. There was no difference in these symptoms when comparing patients with and without GS. When evaluating IBD-related factors, GS was associated with having had a recent flare (adjusted odds ratio [aOR] 7.4; 95% confidence interval [CI] 1.6-34.1), stenotic disease in CD (aOR 4.7; 95% CI 1.1-20.2) and dermatologic manifestations (aOR 5.5; 95% CI 1.2-24.1).
GS was common in IBD and associated with having had a recent flare. GS may be transient for some patients, whereby dietary recommendations during and after a flare could focus on the avoidance of specific food triggers with possible reintroduction of these foods over time. This study prompts further prospective investigation into the temporal evolution of GS in IBD. |
Author | Limketkai, Berkeley N Shah, Neha D Choe, Monica Limsui, David Shah, Shamita Hing, Tressia Sepulveda, Rachel |
Author_xml | – sequence: 1 givenname: Berkeley N orcidid: 0000-0003-2714-6934 surname: Limketkai fullname: Limketkai, Berkeley N organization: a Division of Gastroenterology & Hepatology , Stanford University School of Medicine , Stanford , CA , USA – sequence: 2 givenname: Rachel surname: Sepulveda fullname: Sepulveda, Rachel organization: a Division of Gastroenterology & Hepatology , Stanford University School of Medicine , Stanford , CA , USA – sequence: 3 givenname: Tressia surname: Hing fullname: Hing, Tressia organization: a Division of Gastroenterology & Hepatology , Stanford University School of Medicine , Stanford , CA , USA – sequence: 4 givenname: Neha D surname: Shah fullname: Shah, Neha D organization: b Department of Clinical Nutrition , Stanford Health Care , Palo Alto , CA , USA – sequence: 5 givenname: Monica surname: Choe fullname: Choe, Monica organization: a Division of Gastroenterology & Hepatology , Stanford University School of Medicine , Stanford , CA , USA – sequence: 6 givenname: David surname: Limsui fullname: Limsui, David organization: a Division of Gastroenterology & Hepatology , Stanford University School of Medicine , Stanford , CA , USA – sequence: 7 givenname: Shamita surname: Shah fullname: Shah, Shamita organization: a Division of Gastroenterology & Hepatology , Stanford University School of Medicine , Stanford , CA , USA |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29216767$$D View this record in MEDLINE/PubMed |
BookMark | eNo1j9tKAzEURYMo9qKfoOQHpp4kk8s8StEqFPRB8bHkckYjM5kySVv69xZU2LBf1l6wZ-Q8DQkJuWGwYGDgDkAoKTlbcGB6wWpohKrPyJRJ4JXWYCZklvM3AEhdN5dkwhvOlFZ6Sj5eR9zbDpNHalOgrfVlGDO1OQ8-2oKBHmL5op_drmCiGVOOJe5jOdKYTmk72_f2NDlSNxywoyFmtBmvyEVru4zXfz0n748Pb8unav2yel7erysvlCpVcM7UymBjasbR8eAbZpyxolFBBmi81I6dACYEM-CwlYJ5Hzi0TrfWCT4nt7_e7c71GDbbMfZ2PG7-H_IfL5xVfg |
CitedBy_id | crossref_primary_10_2196_12610 crossref_primary_10_3390_nu16081193 crossref_primary_10_2174_1871523019999201029115618 crossref_primary_10_1002_jpen_2606 crossref_primary_10_1016_j_disamonth_2023_101672 crossref_primary_10_19127_bshealthscience_1362512 crossref_primary_10_1002_fbe2_12000 crossref_primary_10_1093_advances_nmac029 crossref_primary_10_17235_reed_2022_9010_2022 crossref_primary_10_3390_nu13041067 crossref_primary_10_1002_ncp_11146 crossref_primary_10_3390_nu14040751 crossref_primary_10_1093_nutrit_nuab039 crossref_primary_10_3390_nu14194003 crossref_primary_10_1016_j_bpg_2023_101827 crossref_primary_10_3390_nu14204261 crossref_primary_10_1016_j_cgh_2021_06_034 crossref_primary_10_3390_dietetics2020012 crossref_primary_10_1053_j_gastro_2021_05_047 crossref_primary_10_1007_s10620_022_07462_3 crossref_primary_10_1016_j_cgh_2021_03_029 crossref_primary_10_1515_pteridines_2018_0020 crossref_primary_10_1038_s41430_021_01051_9 crossref_primary_10_1136_gutjnl_2018_316360 crossref_primary_10_1097_MEG_0000000000001911 crossref_primary_10_3390_nu16030351 crossref_primary_10_3390_nu13030759 crossref_primary_10_3390_nu11051033 crossref_primary_10_3390_nu15030579 crossref_primary_10_1053_j_gastro_2020_05_016 crossref_primary_10_23736_S2724_5276_20_06166_6 crossref_primary_10_3390_nu11040781 crossref_primary_10_3390_nu13010135 crossref_primary_10_1007_s11938_019_00255_0 crossref_primary_10_1016_j_cgh_2020_01_046 crossref_primary_10_1111_jgh_16414 crossref_primary_10_1016_j_ajg_2024_01_009 crossref_primary_10_1002_mnfr_201901274 crossref_primary_10_1016_j_artmed_2021_102131 crossref_primary_10_3390_nu13072125 crossref_primary_10_3390_nu15245095 |
ContentType | Journal Article |
DBID | NPM |
DOI | 10.1080/00365521.2017.1409364 |
DatabaseName | PubMed |
DatabaseTitle | PubMed |
DatabaseTitleList | PubMed |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
DeliveryMethod | no_fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1502-7708 |
ExternalDocumentID | 29216767 |
Genre | Journal Article |
GroupedDBID | --- .55 00X 03L 0BK 0R~ 123 36B 4.4 5RE AALUX AAMIU AAPUL AAQRR ABBKH ABEIZ ABLIJ ABLJU ABLKL ABOCM ABUPF ABXYU ACENM ACGEJ ACGFO ACGFS ACIEZ ACLSK ADCVX ADRBQ ADXPE AECIN AEGXH AENEX AEOZL AFKVX AFOSN AFWLO AGDLA AGFJD AGRBW AGYJP AIAGR AIJEM AIRBT AJWEG AKBVH ALMA_UNASSIGNED_HOLDINGS ALQZU ALYBC AMDAE BABNJ BLEHA BOHLJ CCCUG CS3 DKSSO DU5 EBS EJD EMOBN F5P H13 HZ~ KRBQP KSSTO KWAYT KYCEM L7B M4Z MJL NPM O9- P2P RNANH RVRKI TBQAZ TDBHL TERGH TFDNU TFL TFW TUROJ UEQFS V1S X7M ~1N |
ID | FETCH-LOGICAL-c366t-dbb8468e98412eb2dc918b8a396d5d09c57b1468133180bef531ccd20fb7fab32 |
IngestDate | Sat Sep 28 08:50:26 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Keywords | Inflammatory bowel disease predictors epidemiology gluten sensitivity gluten-free diet |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c366t-dbb8468e98412eb2dc918b8a396d5d09c57b1468133180bef531ccd20fb7fab32 |
ORCID | 0000-0003-2714-6934 |
PMID | 29216767 |
ParticipantIDs | pubmed_primary_29216767 |
PublicationCentury | 2000 |
PublicationDate | 2018-02-01 |
PublicationDateYYYYMMDD | 2018-02-01 |
PublicationDate_xml | – month: 02 year: 2018 text: 2018-02-01 day: 01 |
PublicationDecade | 2010 |
PublicationPlace | England |
PublicationPlace_xml | – name: England |
PublicationTitle | Scandinavian journal of gastroenterology |
PublicationTitleAlternate | Scand J Gastroenterol |
PublicationYear | 2018 |
SSID | ssj0005749 |
Score | 2.4415789 |
Snippet | Gluten sensitivity (GS) arises with celiac disease and has also been found in non-celiac disorders, although its characteristics in inflammatory bowel disease... |
SourceID | pubmed |
SourceType | Index Database |
StartPage | 1 |
Title | Prevalence and factors associated with gluten sensitivity in inflammatory bowel disease |
URI | https://www.ncbi.nlm.nih.gov/pubmed/29216767 |
hasFullText | |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LaxsxEBZOC6WX0nebPtCht7JhJe1DOqYhxZTWlzg0t6BnYozXxlkaCP3xndFq7U1w6eOyLCsQi-bTaCR98w0hH5TlVpXWZJXVeYaC5Jk2OmQsGMVghfCwm0O2xaQanxZfzsqz0ejnMLukNQf2Zmdeyf9YFb6BXTFL9h8su-kUPsA72BeeYGF4_pWNUX9Jx6yheAfQ187Rach7ZvkF_INvPl4hVz0Vi5ghwTEAGhbdLbtZXvvbtzUpYD2xMe9F_5ilE_sUvV7oq3a9REHP9a2D-a-zxdy3867I9Se_nnv0Otv7Hr9CLrbrQlYUk94wPMapuso0MnM3q8XJpY4nPxN_qRM9OR1SMNnzmnGNSY41x0g-lwNnyXa68J7zKKoSQgsk39UHqMolOrXzgVlXi2hXrjhD2bk_t95R1u6b9sheLdE7TvCkp6cH1YXqM75Qi33X_6CSdOrjzq4kRifTx-RR2lbQww4jT8jIN0_Jg2-JOPGMfN9ChYJBaYIK3UKFIlRoBxU6gAqdNXQIFRqhQhNUnpPTz8fTo3GWampkVlRVmzljIOKUXsmCcZiHziomjdRCVa50ubJlbTAbjwlw9rnxAXy0tY7nwdRBG8FfkHvNsvGvCBUiOFm5ykvui5prCT0xrUqhfeCFda_Jy25IzledcMp5P1j7v215Qx5u4fOW3A8wU_07CPta8z7a5xeJDVo8 |
link.rule.ids | 786 |
linkProvider | National Library of Medicine |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Prevalence+and+factors+associated+with+gluten+sensitivity+in+inflammatory+bowel+disease&rft.jtitle=Scandinavian+journal+of+gastroenterology&rft.au=Limketkai%2C+Berkeley+N&rft.au=Sepulveda%2C+Rachel&rft.au=Hing%2C+Tressia&rft.au=Shah%2C+Neha+D&rft.date=2018-02-01&rft.eissn=1502-7708&rft.spage=1&rft_id=info:doi/10.1080%2F00365521.2017.1409364&rft_id=info%3Apmid%2F29216767&rft_id=info%3Apmid%2F29216767&rft.externalDocID=29216767 |